Literature DB >> 579979

Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.

H G Neumann, M Metzler, W Töpner.   

Abstract

Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds.

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Year:  1977        PMID： 579979     DOI： 10.1007/bf00343272

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  27 in total

1.  Proceedings: The metabolic activation of the double bond of carcinogenic stilbenes.

Authors:  M Metzler; H G Neumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

Review 2.  Carcinogenesis by aromatic amines.

Authors:  E Kriek
Journal:  Biochim Biophys Acta       Date:  1974-09-09

3.  Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase.

Authors:  C M King
Journal:  Cancer Res       Date:  1974-06       Impact factor: 12.701

4.  Clear-cell adenocarcinoma of the genital tract in young females. Registry report.

Authors:  A L Herbst; R J Kurman; R E Scully; D C Poskanzer
Journal:  N Engl J Med       Date:  1972-12-21       Impact factor: 91.245

5.  N'-hydroxy-2-aminofluorene: the principal mutagen produced from N-hydroxy-2-acetylaminofluorene by a mammalian supernatant enzyme preparation.

Authors:  D L Stout; J N Baptist; T S Matney; C R Shaw
Journal:  Cancer Lett       Date:  1976-05       Impact factor: 8.679

6.  Oxidative metabolites of diethylstilbestrol in the fetal, neonatal and adult mouse.

Authors:  M Metzler; J A McLachlan
Journal:  Biochem Pharmacol       Date:  1978-04-01       Impact factor: 5.858

7.  Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor.

Authors:  S Osterman-Golkar; L Ehrenberg; D Segerbäck; I Hällström
Journal:  Mutat Res       Date:  1976-01       Impact factor: 2.433

8.  Metabolic epoxidation of trans-4-acetylaminostilbene: a protective mechanism against its activation to a mutagen.

Authors:  H R Glatt; M Metzler; H G Neumann; F Oesch
Journal:  Biochem Biophys Res Commun       Date:  1976-12-20       Impact factor: 3.575

9.  A simple method for the detection of mutagens in urine: studies with the carcinogen 2-acetylaminofluorene.

Authors:  W E Durston; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

10.  N-acetoxy-N-acetylaminoarenes and nitrosoarenes. One-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids.

Authors:  H Bartsch; J A Miller; E C Miller
Journal:  Biochim Biophys Acta       Date:  1972-06-26
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  5 in total

1.  Biomonitoring of aromatic amines and alkylating agents by measuring hemoglobin adducts.

Authors:  H G Neumann
Journal:  Int Arch Occup Environ Health       Date:  1988       Impact factor: 3.015

2.  Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring.

Authors:  J Lewalter; U Korallus
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

3.  Analysis of hemoglobin as a dose monitor for alkylating and arylating agents.

Authors:  H G Neumann
Journal:  Arch Toxicol       Date:  1984-11       Impact factor: 5.153

4.  Hydrolyzable hemoglobin adducts of polyfunctional monocyclic N-substituted arenes as dosimeters of exposure and markers of metabolism.

Authors:  I Zwirner-Baier; F J Kordowich; H G Neumann
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031

Review 5.  Reactions of oxidatively activated arylamines with thiols: reaction mechanisms and biologic implications. An overview.

Authors:  P Eyer
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031
  5 in total

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