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Literature DB >> 3097024

DNA adducts of medicinal drugs: some selected examples.

Abstract

A few selected medicinal drugs, diamminedichloroplatinum (II) compounds, mitomycin C, psoralens, and diethylstilbestrol are briefly reviewed with respect to the formation and biological significance of their DNA adducts. Different types of adducts, e.g., DNA intrastrand crosslinks, DNA interstrand crosslinks, or monoadducts appear to represent the critical DNA lesions of the different drugs, accounting for cytotoxicity and carcinogenicity. Thus, these examples serve to illustrate the complexity of DNA adduct formation and its biological sequelae.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1986 PMID： 3097024 DOI： 10.1007/bf00395914

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

23 in total

Review 1. Photochemistry and photobiology of psoralens.

Authors: P S Song; K J Tapley
Journal: Photochem Photobiol Date: 1979-06 Impact factor: 3.421

2. Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II).

Authors: A Eastman
Journal: Biochemistry Date: 1983-08-02 Impact factor: 3.162

3. Modification of deoxyribonucleic acid with reductively activated mitomycin C. Structures of modified nucleotides.

Authors: Y Hashimoto; K Shudo; T Okamoto
Journal: Chem Pharm Bull (Tokyo) Date: 1983-03 Impact factor: 1.645

4. Structure of a psoralen-thymine monoadduct formed in photoreaction with DNA.

Authors: S Peckler; B Graves; D Kanne; H Rapoport; J E Hearst; S H Kim
Journal: J Mol Biol Date: 1982-11-25 Impact factor: 5.469

5. Covalent binding of diethylstilbestrol to DNA in rat and hamster liver and kidney.

Authors: W K Lutz; W Jaggi; C Schlatter
Journal: Chem Biol Interact Date: 1982-11 Impact factor: 5.192

6. Possible role of oxygen radicals in cell transformation by diethylstilbestrol and related compounds.

Authors: B Epe; D Schiffmann; M Metzler
Journal: Carcinogenesis Date: 1986-08 Impact factor: 4.944

Review 7. Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA.

Authors: A L Pinto; S J Lippard
Journal: Biochim Biophys Acta Date: 1985

8. Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.

Authors: A C Plooy; M van Dijk; P H Lohman
Journal: Cancer Res Date: 1984-05 Impact factor: 12.701

9. Psoralen-deoxyribonucleic acid photoreaction. Characterization of the monoaddition products from 8-methoxypsoralen and 4,5'8-trimethylpsoralen.

Authors: D Kanne; K Straub; H Rapoport; J E Hearst
Journal: Biochemistry Date: 1982-03-02 Impact factor: 3.162

10. Postlabeling methods for carcinogen-DNA adduct analysis.

Authors: K Randerath; E Randerath; H P Agrawal; R C Gupta; M E Schurdak; M V Reddy
Journal: Environ Health Perspect Date: 1985-10 Impact factor: 9.031

5 in total

1. DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links.

Authors: Y M Akkari; R L Bateman; C A Reifsteck; S B Olson; M Grompe
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

2. Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.

Authors: Andreas Rothfuss; Markus Grompe
Journal: Mol Cell Biol Date: 2004-01 Impact factor: 4.272

3. Limited Capacity or Involvement of Excision Repair, Double-Strand Breaks, or Translesion Synthesis for Psoralen Cross-Link Repair in Escherichia coli.

Authors: Jessica M Cole; Jedidiah D Acott; Charmain T Courcelle; Justin Courcelle
Journal: Genetics Date: 2018-07-25 Impact factor: 4.562

4. Loss of homologous recombination or non-homologous end-joining leads to radial formation following DNA interstrand crosslink damage.

Authors: A E Hanlon Newell; A Hemphill; Y M N Akkari; J Hejna; R E Moses; S B Olson
Journal: Cytogenet Genome Res Date: 2008-08-28 Impact factor: 1.636

5. BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells.

Authors: Akiko Horiuchi; Cuiju Wang; Norihiko Kikuchi; Ryosuke Osada; Toshio Nikaido; Ikuo Konishi
Journal: Biomark Insights Date: 2007-03-02

5 in total