Literature DB >> 9812762

Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Q Liu1, T Lei, E F Adams, M Buchfedlder, R Fahlbusch.   

Abstract

Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by pituitary somatotrophs. Phorbel ester, 1, 2 tetradecanoylphorbol 13 acetate (TPA) can also stimulate releasing of GH. The precise intracellular mechanism has not been entirely deciphered. We used cell cultures of human pituitary somatotrophinomas to investigate the relation between GHRP-6 and TPA on membrane phosphatidylinositol (PI) turnover and GH secretion. The results showed that the working mechanisms of GHRP-6 and TPA are not identical, although they all can stimulate GH secretion in human pituitary somatotrophinomas. This indicates that PI-PKC signal transduction system may play a crucial role in the regulation of GH secretion.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9812762     DOI： 10.1007/bf02888286

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  9 in total

Review 1.  Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.

Authors:  Y Nishizuka
Journal:  Science       Date:  1992-10-23       Impact factor: 47.728

2.  Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways.

Authors:  E F Adams; T Lei; M Buchfelder; C Y Bowers; R Fahlbusch
Journal:  Mol Endocrinol       Date:  1996-04

3.  Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Authors:  T Lei; E F Adams; M Buchfelder; R Fahlbusch
Journal:  Neurosurgery       Date:  1996-09       Impact factor: 4.654

4.  Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.

Authors:  N Emoto; E Ohmura; O Isozaki; T Tsushima; K Shizume; H Demura
Journal:  Clin Endocrinol (Oxf)       Date:  1991-05       Impact factor: 3.478

5.  The growth hormone secretagogue, L-692,429, induces phosphatidylinositol hydrolysis and hormone secretion by human pituitary tumors.

Authors:  E F Adams; B Petersen; T Lei; M Buchfelder; R Fahlbusch
Journal:  Biochem Biophys Res Commun       Date:  1995-03-17       Impact factor: 3.575

6.  Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells.

Authors:  K Cheng; W W Chan; B Butler; A Barreto; R G Smith
Journal:  Endocrinology       Date:  1991-12       Impact factor: 4.736

7.  A receptor in pituitary and hypothalamus that functions in growth hormone release.

Authors:  A D Howard; S D Feighner; D F Cully; J P Arena; P A Liberator; C I Rosenblum; M Hamelin; D L Hreniuk; O C Palyha; J Anderson; P S Paress; C Diaz; M Chou; K K Liu; K K McKee; S S Pong; L Y Chaung; A Elbrecht; M Dashkevicz; R Heavens; M Rigby; D J Sirinathsinghji; D C Dean; D G Melillo; A A Patchett; R Nargund; P R Griffin; J A DeMartino; S K Gupta; J M Schaeffer; R G Smith; L H Van der Ploeg
Journal:  Science       Date:  1996-08-16       Impact factor: 47.728

8.  Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: in vitro cell culture studies.

Authors:  E F Adams; T Lei; M Buchfelder; B Petersen; R Fahlbusch
Journal:  J Clin Endocrinol Metab       Date:  1995-07       Impact factor: 5.958

9.  Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells.

Authors:  T Lei; M Buchfelder; R Fahlbusch; E F Adams
Journal:  J Mol Endocrinol       Date:  1995-02       Impact factor: 5.098
  9 in total
  6 in total

1.  Preliminary study on the relationship between cAMP level and gsp expression in cultured human pituitary somatotrophinomas.

Authors:  T Lei; Q Liu; L Li; L Zhang; K Shu; D Xue
Journal:  J Tongji Med Univ       Date:  2000

2.  GHRP-6 induces CREB phosphorylation and growth hormone secretion via a protein kinase Csigma-dependent pathway in GH3 cells.

Authors:  Chunlei Tian; Fei Ye; Tongjiang Xu; Sheng Wang; Xiaodan Wang; Heping Wang; Feng Wan; Ting Lei
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2010-04-21

3.  The role of protein kinase C and its effect on GHRH in the regulation of hormone secretion by somatotrophinomas.

Authors:  K Liu; Q Liu; X Bai; T Lei; D Xue
Journal:  J Tongji Med Univ       Date:  2000

4.  Interaction of the novel GH secretagogue hexarelin with GHRH in regulating the secretion of GH by cultured human pituitary somatotrophinomas in vitro.

Authors:  Q Liu; T Lei; K Liu; W Lin; E F Adams
Journal:  J Tongji Med Univ       Date:  2000

5.  Effects of the novel GH secretogogue, hexarelin on GH secretion and phosphatidylinositol hydrolysis by human pituitary somatotrophinomas in cell culture.

Authors:  Q Liu; T Lei; K Liu; X Bai; E Adams
Journal:  J Tongji Med Univ       Date:  1999

6.  The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.

Authors:  Q Liu; X Bai; K Liu; W Lin; T Lei
Journal:  J Tongji Med Univ       Date:  1999
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.