Literature DB >> 12845746

The role of protein kinase C and its effect on GHRH in the regulation of hormone secretion by somatotrophinomas.

K Liu1, Q Liu, X Bai, T Lei, D Xue.   

Abstract

Phorbol ester-induced release of growth hormone (GH) and prolactin (PRL) from human somatotrophic tumors was examined in vitro. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). In contrast, staurosporine exerted a variable inhibitory effect on GH release. There was no correlation between such effects and gsp mutations. The findings suggested that TPA doesn't act directly through cAMP signal transduction system.

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Year:  2000        PMID： 12845746     DOI： 10.1007/bf02887665

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  10 in total

1.  GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

Authors:  C A Landis; S B Masters; A Spada; A M Pace; H R Bourne; L Vallar
Journal:  Nature       Date:  1989-08-31       Impact factor: 49.962

2.  Hormone secretion by cell culture of human GH-PRL secreting pituitary adenomas: effects of bromocriptine.

Authors:  T Lei; X Bai; K Liu; W Hu; D Xue; X Jiang
Journal:  J Tongji Med Univ       Date:  1998

3.  Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Authors:  T Lei; E F Adams; M Buchfelder; R Fahlbusch
Journal:  Neurosurgery       Date:  1996-09       Impact factor: 4.654

4.  Phorbol ester, not growth hormone releasing factor, consistently stimulates growth hormone release from somatotroph adenomas in culture.

Authors:  N Emoto; E Ohmura; O Isozaki; T Tsushima; K Shizume; H Demura
Journal:  Clin Endocrinol (Oxf)       Date:  1991-05       Impact factor: 3.478

5.  Growth hormone-releasing factor does not activate protein kinase C in somatotrophs.

Authors:  M B French; B C Moor; B T Lussier; J Kraicer
Journal:  Mol Cell Endocrinol       Date:  1991-08       Impact factor: 4.102

6.  Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

Authors:  W B Butler; W H Kelsey; N Goran
Journal:  Cancer Res       Date:  1981-01       Impact factor: 12.701

7.  Protein kinase C activity and expression in normal and adenomatous human pituitaries.

Authors:  V Alvaro; P Touraine; R Raisman Vozari; F Bai-Grenier; P Birman; D Joubert
Journal:  Int J Cancer       Date:  1992-03-12       Impact factor: 7.396

8.  Biochemical characteristics of human pituitary somatotropinomas with and without gsp mutations: in vitro cell culture studies.

Authors:  E F Adams; T Lei; M Buchfelder; B Petersen; R Fahlbusch
Journal:  J Clin Endocrinol Metab       Date:  1995-07       Impact factor: 5.958

9.  Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Authors:  Q Liu; T Lei; E F Adams; M Buchfedlder; R Fahlbusch
Journal:  J Tongji Med Univ       Date:  1997

10.  Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells.

Authors:  T Lei; M Buchfelder; R Fahlbusch; E F Adams
Journal:  J Mol Endocrinol       Date:  1995-02       Impact factor: 5.098
  10 in total

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