Literature DB >> 12938517

The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.

Q Liu1, X Bai, K Liu, W Lin, T Lei.   

Abstract

Growth hormone releasing peptide (GHRP-2) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by fetal pituitary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors. We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different. This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.

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Year:  1999        PMID： 12938517     DOI： 10.1007/bf02886962

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  7 in total

Review 1.  Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.

Authors:  Y Nishizuka
Journal:  Science       Date:  1992-10-23       Impact factor: 47.728

2.  Cloning of the growth hormone secretagogues receptor cDNA: new evidence for a third endocrine pathway controlling growth hormone release.

Authors:  J Bertherat
Journal:  Eur J Endocrinol       Date:  1997-01       Impact factor: 6.664

3.  Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways.

Authors:  E F Adams; T Lei; M Buchfelder; C Y Bowers; R Fahlbusch
Journal:  Mol Endocrinol       Date:  1996-04

4.  Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Authors:  T Lei; E F Adams; M Buchfelder; R Fahlbusch
Journal:  Neurosurgery       Date:  1996-09       Impact factor: 4.654

5.  A receptor in pituitary and hypothalamus that functions in growth hormone release.

Authors:  A D Howard; S D Feighner; D F Cully; J P Arena; P A Liberator; C I Rosenblum; M Hamelin; D L Hreniuk; O C Palyha; J Anderson; P S Paress; C Diaz; M Chou; K K Liu; K K McKee; S S Pong; L Y Chaung; A Elbrecht; M Dashkevicz; R Heavens; M Rigby; D J Sirinathsinghji; D C Dean; D G Melillo; A A Patchett; R Nargund; P R Griffin; J A DeMartino; S K Gupta; J M Schaeffer; R G Smith; L H Van der Ploeg
Journal:  Science       Date:  1996-08-16       Impact factor: 47.728

6.  Relationship between GHRP-6 and TPA in the regulation of growth hormone secretion by human pituitary somatotrophinomas.

Authors:  Q Liu; T Lei; E F Adams; M Buchfedlder; R Fahlbusch
Journal:  J Tongji Med Univ       Date:  1997

7.  Growth hormone releasing peptide (GHRP-6) stimulates phosphatidylinositol (PI) turnover in human pituitary somatotroph cells.

Authors:  T Lei; M Buchfelder; R Fahlbusch; E F Adams
Journal:  J Mol Endocrinol       Date:  1995-02       Impact factor: 5.098
  7 in total
  2 in total

1.  Preliminary study on the relationship between cAMP level and gsp expression in cultured human pituitary somatotrophinomas.

Authors:  T Lei; Q Liu; L Li; L Zhang; K Shu; D Xue
Journal:  J Tongji Med Univ       Date:  2000

2.  GHRP-6 induces CREB phosphorylation and growth hormone secretion via a protein kinase Csigma-dependent pathway in GH3 cells.

Authors:  Chunlei Tian; Fei Ye; Tongjiang Xu; Sheng Wang; Xiaodan Wang; Heping Wang; Feng Wan; Ting Lei
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2010-04-21
  2 in total

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