| Literature DB >> 8688086 |
A D Howard1, S D Feighner, D F Cully, J P Arena, P A Liberator, C I Rosenblum, M Hamelin, D L Hreniuk, O C Palyha, J Anderson, P S Paress, C Diaz, M Chou, K K Liu, K K McKee, S S Pong, L Y Chaung, A Elbrecht, M Dashkevicz, R Heavens, M Rigby, D J Sirinathsinghji, D C Dean, D G Melillo, A A Patchett, R Nargund, P R Griffin, J A DeMartino, S K Gupta, J M Schaeffer, R G Smith, L H Van der Ploeg.
Abstract
Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.Entities:
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Year: 1996 PMID： 8688086 DOI： 10.1126/science.273.5277.974
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728