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Literature DB >> 9789017

Folding and aggregation of designed proteins.

R A Broglia¹, G Tiana, S Pasquali, H E Roman, E Vigezzi.

Abstract

Protein aggregation is studied by following the simultaneous folding of two designed identical 20-letter amino acid chains within the framework of a lattice model and using Monte Carlo simulations. It is found that protein aggregation is determined by elementary structures (partially folded intermediates) controlled by local contacts among some of the most strongly interacting amino acids and formed at an early stage in the folding process.

Entities: Disease

Mesh：

Substances：
Peptides
Proteins

Year: 1998 PMID： 9789017 PMCID： PMC23658 DOI： 10.1073/pnas.95.22.12930

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

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Authors: H Taketomi; Y Ueda; N Gō
Journal: Int J Pept Protein Res Date: 1975

2. Proteins with selected sequences fold into unique native conformation.

Authors:
Journal: Phys Rev Lett Date: 1994-06-13 Impact factor: 9.161

Review 3. For protein misassembly, it's the "I" decade.

Authors: R Wetzel
Journal: Cell Date: 1996-09-06 Impact factor: 41.582

Review 4. Protein aggregation: folding aggregates, inclusion bodies and amyloid.

Authors: A L Fink
Journal: Fold Des Date: 1998

5. Transient aggregates in protein folding are easily mistaken for folding intermediates.

Authors: M Silow; M Oliveberg
Journal: Proc Natl Acad Sci U S A Date: 1997-06-10 Impact factor: 11.205

6. Theory of cooperative transitions in protein molecules. I. Why denaturation of globular protein is a first-order phase transition.

Authors: E I Shakhnovich; A V Finkelstein
Journal: Biopolymers Date: 1989-10 Impact factor: 2.505

7. Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.

Authors: S L McCutchen; Z Lai; G J Miroy; J W Kelly; W Colón
Journal: Biochemistry Date: 1995-10-17 Impact factor: 3.162

Review 8. Mutations and off-pathway aggregation of proteins.

Authors: R Wetzel
Journal: Trends Biotechnol Date: 1994-05 Impact factor: 19.536

9. Conserved residues and the mechanism of protein folding.

Authors: E Shakhnovich; V Abkevich; O Ptitsyn
Journal: Nature Date: 1996-01-04 Impact factor: 49.962

10. Folding pathway of human alpha 1-antitrypsin: characterization of an intermediate that is active but prone to aggregation.

Authors: D Kim; M H Yu
Journal: Biochem Biophys Res Commun Date: 1996-09-13 Impact factor: 3.575

15 in total

1. Conformational propagation with prion-like characteristics in a simple model of protein folding.

Authors: P M Harrison; H S Chan; S B Prusiner; F E Cohen
Journal: Protein Sci Date: 2001-04 Impact factor: 6.725

2. Exploring protein aggregation and self-propagation using lattice models: phase diagram and kinetics.

Authors: R I Dima; D Thirumalai
Journal: Protein Sci Date: 2002-05 Impact factor: 6.725

3. The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35.

Authors: Jörg Gsponer; Urs Haberthür; Amedeo Caflisch
Journal: Proc Natl Acad Sci U S A Date: 2003-04-16 Impact factor: 11.205

4. Solvent-amino acid interaction energies in three-dimensional-lattice Monte Carlo simulations of a model 27-mer protein: Folding thermodynamics and kinetics.

Authors: Kai Leonhard; John M Prausnitz; Clayton J Radke
Journal: Protein Sci Date: 2004-02 Impact factor: 6.725