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Literature DB >> 9566607

Protection against developmental deficiencies by a lipophilic VIP analogue.

I Gozes¹, M Bachar, A Bardea, A Davidson, S Rubinraut, M Fridkin.

Abstract

Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vivo using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 1998 PMID： 9566607 DOI： 10.1023/a:1022494907001

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

33 in total

1. Vasoactive intestinal peptide gene expression from embryos to aging rats.

Authors: I Gozes; P Schächter; Y Shani; E Giladi
Journal: Neuroendocrinology Date: 1988-01 Impact factor: 4.914

2. Vasoactive intestinal peptide antagonist retards the development of neonatal behaviors in the rat.

Authors: J M Hill; I Gozes; J L Hill; M Fridkin; D E Brenneman
Journal: Peptides Date: 1991 Jan-Feb Impact factor: 3.750

3. Superactive lipophilic peptides discriminate multiple vasoactive intestinal peptide receptors.

Authors: I Gozes; G Lilling; R Glazer; A Ticher; I E Ashkenazi; A Davidson; S Rubinraut; M Fridkin; D E Brenneman
Journal: J Pharmacol Exp Ther Date: 1995-04 Impact factor: 4.030

Review 4. Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells.

Authors: P J Magistretti; O Sorg; N Yu; J L Martin; L Pellerin
Journal: Dev Neurosci Date: 1993 Impact factor: 2.984

5. Spontaneous electrical activity regulates vasoactive intestinal peptide expression in dissociated spinal cord cell cultures.

Authors: D V Agoston; L E Eiden; D E Brenneman; I Gozes
Journal: Brain Res Mol Brain Res Date: 1991-06

6. Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist.

Authors: J R Glowa; L V Panlilio; D E Brenneman; I Gozes; M Fridkin; J M Hill
Journal: Brain Res Date: 1992-01-20 Impact factor: 3.252

7. Neurotrophic action of VIP on spinal cord cultures.

Authors: D E Brenneman; L E Eiden; R E Siegel
Journal: Peptides Date: 1985 Impact factor: 3.750

8. Differential involvement of the arachidonic acid cascade on the alpha 1-adrenergic potentiation of vasoactive intestinal peptide- versus beta-adrenergic-stimulated cyclic AMP and cyclic GMP accumulation in rat pinealocytes.

Authors: C L Chik; I Young; A K Ho
Journal: J Neurochem Date: 1991-11 Impact factor: 5.372

Review 2. From vasoactive intestinal peptide (VIP) through activity-dependent neuroprotective protein (ADNP) to NAP: a view of neuroprotection and cell division.

Authors: Illana Gozes; Inna Divinsky; Inbar Pilzer; Mati Fridkin; Douglas E Brenneman; Avron D Spier
Journal: J Mol Neurosci Date: 2003 Impact factor: 2.866

2 in total