Literature DB >> 2052494

Vasoactive intestinal peptide antagonist retards the development of neonatal behaviors in the rat.

J M Hill1, I Gozes, J L Hill, M Fridkin, D E Brenneman.   

Abstract

Based on the demonstrated neurotrophic activity of VIP in vitro, a recently designed VIP antagonist was used to assess the role of this neuropeptide in the behavioral development of rats. Rats received daily subcutaneous injections from birth to day 14. Observations of developmental milestones/behaviors were made daily for 21 days. Of the measures of behavioral development tested, the time to surface right on day 4 and the day of onset for forelimb placing, hindlimb placing, forelimb grasping and air righting were significantly retarded by the antagonist. Cotreatment with VIP prevented the antagonist-induced delay. These results suggest that VIP activity is important in the development of select complex motor behaviors.

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Year:  1991        PMID： 2052494     DOI： 10.1016/0196-9781(91)90186-s

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  20 in total

1.  Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate.

Authors:  P Kiss; A Tamas; A Lubics; M Szalai; L Szalontay; I Lengvari; D Reglodi
Journal:  Neurotox Res       Date:  2005-11       Impact factor: 3.911

2.  VIP, from gene to behavior and back: summarizing my 25 years of research.

Authors:  Illana Gozes
Journal:  J Mol Neurosci       Date:  2008-07-08       Impact factor: 3.444

Review 3.  A VIP hybrid antagonist: from developmental neurobiology to clinical applications.

Authors:  I Gozes; M Fridkin; D E Brenneman
Journal:  Cell Mol Neurobiol       Date:  1995-12       Impact factor: 5.046

4.  Protection against developmental deficiencies by a lipophilic VIP analogue.

Authors:  I Gozes; M Bachar; A Bardea; A Davidson; S Rubinraut; M Fridkin
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

5.  Ontogeny of vasoactive intestinal peptide gene expression in rat brain.

Authors:  M Graber; J M Burgunder
Journal:  Anat Embryol (Berl)       Date:  1996-12

6.  Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain.

Authors:  P Gressens; S Marret; J M Hill; D E Brenneman; I Gozes; M Fridkin; P Evrard
Journal:  J Clin Invest       Date:  1997-07-15       Impact factor: 14.808

Review 7.  Neuropeptides as growth and differentiation factors in general and VIP in particular.

Authors:  I Gozes; D E Brenneman
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444

8.  Learning and sexual deficiencies in transgenic mice carrying a chimeric vasoactive intestinal peptide gene.

Authors:  I Gozes; J Glowa; D E Brenneman; S K McCune; E Lee; H Westphal
Journal:  J Mol Neurosci       Date:  1993       Impact factor: 3.444

9.  Severe microcephaly induced by blockade of vasoactive intestinal peptide function in the primitive neuroepithelium of the mouse.

Authors:  P Gressens; J M Hill; B Paindaveine; I Gozes; M Fridkin; D E Brenneman
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

10.  Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior.

Authors:  Maria A Lim; Conor M Stack; Katrina Cuasay; Madeleine M Stone; Hewlet G McFarlane; James A Waschek; Joanna M Hill
Journal:  Int J Dev Neurosci       Date:  2008-03-14       Impact factor: 2.457
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