Literature DB >> 18607776

VIP, from gene to behavior and back: summarizing my 25 years of research.

Illana Gozes1.   

Abstract

Vasoactive intestinal peptide (VIP) is an interesting example of a 28-amino acid neuropeptide that is abundantly expressed in discrete brain regions/neurons and hence may contribute to brain function. This short review summarizes my own point of view and encompasses 25 years of work and over 100 publications targeting the understanding of VIP production and biological activity. The review starts with our original cloning of the VIP gene, it then continues to discoveries of regulation of VIP synthesis and the establishment of the first VIP transgenic mice. The review ends with the identification of novel VIP analogs that helped decipher VIP's important role during development, in regulation of the biological clock(s) and diurnal rhythms, sexual activity, learning and memory as well as social behavior, and cancer. This review cites only articles that I have coauthored and gives my own perspective of this exciting ever-growing field.

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Year:  2008        PMID： 18607776     DOI： 10.1007/s12031-008-9105-3

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  115 in total

1.  An antagonist to vasoactive intestinal peptide affects cellular functions in the central nervous system.

Authors:  I Gozes; S K McCune; L Jacobson; D Warren; T W Moody; M Fridkin; D E Brenneman
Journal:  J Pharmacol Exp Ther       Date:  1991-06       Impact factor: 4.030

2.  Neurobehavioral development of neonatal mice following blockade of VIP during the early embryonic period.

Authors:  J Y Wu; K A Henins; P Gressens; I Gozes; M Fridkin; D E Brenneman; J M Hill
Journal:  Peptides       Date:  1997       Impact factor: 3.750

3.  Vasoactive intestinal peptide gene expression from embryos to aging rats.

Authors:  I Gozes; P Schächter; Y Shani; E Giladi
Journal:  Neuroendocrinology       Date:  1988-01       Impact factor: 4.914

4.  Localization of VIP and PHI-27 messenger RNA in rat thalamic and cortical neurons.

Authors:  F Baldino; S Fitzpatrick-McElligott; I Gozes; J P Card
Journal:  J Mol Neurosci       Date:  1989       Impact factor: 3.444

5.  Vasoactive intestinal peptide antagonist retards the development of neonatal behaviors in the rat.

Authors:  J M Hill; I Gozes; J L Hill; M Fridkin; D E Brenneman
Journal:  Peptides       Date:  1991 Jan-Feb       Impact factor: 3.750

6.  Superactive lipophilic peptides discriminate multiple vasoactive intestinal peptide receptors.

Authors:  I Gozes; G Lilling; R Glazer; A Ticher; I E Ashkenazi; A Davidson; S Rubinraut; M Fridkin; D E Brenneman
Journal:  J Pharmacol Exp Ther       Date:  1995-04       Impact factor: 4.030

7.  Hypothalamic vasoactive intestinal peptide messenger ribonucleic acid is increased in lactating rats.

Authors:  I Gozes; Y Shani
Journal:  Endocrinology       Date:  1986-12       Impact factor: 4.736

8.  Novel analogs of VIP with multiple C-terminal domains.

Authors:  David Dangoor; Sara Rubinraut; Mati Fridkin; Illana Gozes
Journal:  Peptides       Date:  2007-03-30       Impact factor: 3.750

9.  High levels of vasoactive intestinal peptide in human milk.

Authors:  H Werner; Y Koch; M Fridkin; J Fahrenkrug; I Gozes
Journal:  Biochem Biophys Res Commun       Date:  1985-11-27       Impact factor: 3.575

10.  VPAC1 receptors and lung cancer.

Authors:  T W Moody; J Walters; M Casibang; F Zia; Y Gozes
Journal:  Ann N Y Acad Sci       Date:  2000       Impact factor: 5.691
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  11 in total

1.  VIP-PACAP 2010: my own perspective on modulation of cognitive and emotional behavior.

Authors:  Illana Gozes
Journal:  J Mol Neurosci       Date:  2010-11       Impact factor: 3.444

2.  Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.

Authors:  Rafael Fernandez-Montesinos; Manuel Torres; David Baglietto-Vargas; Antonia Gutierrez; Illana Gozes; Javier Vitorica; David Pozo
Journal:  J Mol Neurosci       Date:  2009-10-21       Impact factor: 3.444

Review 3.  VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies.

Authors:  Terry W Moody; Tetsuhide Ito; Nuramy Osefo; Robert T Jensen
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2011-02       Impact factor: 3.243

4.  Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice.

Authors:  Agnes Kemény; Dóra Reglodi; Renáta Cseharovszky; Hitoshi Hashimoto; Akemichi Baba; János Szolcsányi; Erika Pintér; Zsuzsanna Helyes
Journal:  J Mol Neurosci       Date:  2010-04-23       Impact factor: 3.444

5.  The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules.

Authors:  Mythili Yenjerla; Nichole E LaPointe; Manu Lopus; Corey Cox; Mary Ann Jordan; Stuart C Feinstein; Leslie Wilson
Journal:  J Alzheimers Dis       Date:  2010       Impact factor: 4.472

6.  Vasoactive intestinal polypeptide immunoreactivity in the human cerebellum: qualitative and quantitative analyses.

Authors:  Vincenzo Benagiano; Paolo Flace; Loredana Lorusso; Anna Rizzi; Lorenzo Bosco; Raffaele Cagiano; Glauco Ambrosi
Journal:  J Anat       Date:  2009-06-22       Impact factor: 2.610

7.  Neuropeptide GPCRs in neuroendocrinology: the case of activity-dependent neuroprotective protein (ADNP).

Authors:  Illana Gozes
Journal:  Front Endocrinol (Lausanne)       Date:  2012-11-16       Impact factor: 5.555

8.  Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation.

Authors:  Yulie Schirer; Anna Malishkevich; Yotam Ophir; Jada Lewis; Eliezer Giladi; Illana Gozes
Journal:  PLoS One       Date:  2014-01-29       Impact factor: 3.240

9.  Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children.

Authors:  I Gozes; A Van Dijck; G Hacohen-Kleiman; I Grigg; G Karmon; E Giladi; M Eger; Y Gabet; M Pasmanik-Chor; E Cappuyns; O Elpeleg; R F Kooy; S Bedrosian-Sermone
Journal:  Transl Psychiatry       Date:  2017-02-21       Impact factor: 6.222

10.  mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction.

Authors:  Dong Liu; Adam Stowie; Nuria de Zavalia; Tanya Leise; Salil Saurav Pathak; Lester R Drewes; Alec J Davidson; Shimon Amir; Nahum Sonenberg; Ruifeng Cao
Journal:  Proc Natl Acad Sci U S A       Date:  2018-03-19       Impact factor: 11.205
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