| Literature DB >> 3340270 |
I Gozes1, P Schächter, Y Shani, E Giladi.
Abstract
Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.Entities:
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Year: 1988 PMID: 3340270 DOI: 10.1159/000124886
Source DB: PubMed Journal: Neuroendocrinology ISSN: 0028-3835 Impact factor: 4.914