OBJECTIVE: Because our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specimens. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyze the PDGF-A gene expression in 65 gastric carcinoma endoscopic biopsy specimens. The 65 patients were divided into a PDGF-A-positive group (29 patients) and a PDGF-A-negative group (36 patients). RESULTS: On the basis of 2-year follow-up data, the PDGF-A-positive group demonstrated a shorter overall survival rate compared with the PDGF-A-negative group (p < 0.0001). A similar correlation was found in 34 advanced-stage patients (p = 0.003) and in 24 advanced-stage patients who underwent a curative resection (p = 0.003). Multivariance analysis indicated that the transcription of PDGF-A gene is a potent prognostic factor that is independent of the traditional pathologic parameters. CONCLUSIONS: Expression of PDGF-A mRNA in gastric biopsy specimens may be a new preoperative prognostic parameter in gastric carcinoma.
OBJECTIVE: Because our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specimens. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyze the PDGF-A gene expression in 65 gastric carcinoma endoscopic biopsy specimens. The 65 patients were divided into a PDGF-A-positive group (29 patients) and a PDGF-A-negative group (36 patients). RESULTS: On the basis of 2-year follow-up data, the PDGF-A-positive group demonstrated a shorter overall survival rate compared with the PDGF-A-negative group (p < 0.0001). A similar correlation was found in 34 advanced-stage patients (p = 0.003) and in 24 advanced-stage patients who underwent a curative resection (p = 0.003). Multivariance analysis indicated that the transcription of PDGF-A gene is a potent prognostic factor that is independent of the traditional pathologic parameters. CONCLUSIONS: Expression of PDGF-A mRNA in gastric biopsy specimens may be a new preoperative prognostic parameter in gastric carcinoma.
Authors: S Krüger-Krasagakes; K Krasagakis; C Garbe; E Schmitt; C Hüls; T Blankenstein; T Diamantstein Journal: Br J Cancer Date: 1994-12 Impact factor: 7.640
Authors: C Gómez-Martín; R Salazar; C Montagut; M Gil-Martín; J A Núñez; M Puig; X Lin; R Khosravan; J M Tursi; M J Lechuga; J Bellmunt Journal: Invest New Drugs Date: 2012-05-22 Impact factor: 3.850
Authors: Carl C Schimanski; Friederike Schlaegel; Mareike Jordan; Markus Moehler; George Sgourakis; Daniel G Drescher; Peter R Galle; Hauke Lang; Ines Gockel Journal: World J Surg Date: 2011-05 Impact factor: 3.352
Authors: K-W Lee; S R Park; D-Y Oh; Y-I Park; R Khosravan; X Lin; S-Y Lee; E-J Roh; O Valota; M J Lechuga; Y-J Bang Journal: Invest New Drugs Date: 2013-10-04 Impact factor: 3.850