Literature DB >> 9457871

Comparison of the sensitivities of two Escherichia coli genes to in vivo variation of Lrp concentration.

C Chen1, E B Newman.   

Abstract

Transcription of the Escherichia coli genes serA and gltBDF depends on the leucine-responsive regulatory protein, Lrp, and is very much decreased in an lrp mutant. By the use of an Lrp-deficient host and the lrp gene cloned under a plasmid-borne arabinose pBAD promoter, we varied the amount of Lrp present in the cell and showed that both genes were transcribed in proportion to the amount of Lrp synthesized. The affinity of serA for Lrp was four to five times greater than the affinity of gltD. Overproduction of Lrp was lethal to the cell.

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Year:  1998        PMID： 9457871      PMCID： PMC106935     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

Review 1.  Bacterial growth inhibition by overproduction of protein.

Authors:  C G Kurland; H Dong
Journal:  Mol Microbiol       Date:  1996-07       Impact factor: 3.501

2.  Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.

Authors:  L M Guzman; D Belin; M J Carson; J Beckwith
Journal:  J Bacteriol       Date:  1995-07       Impact factor: 3.490

3.  Identification of Lrp-regulated genes by inverse PCR and sequencing: regulation of two mal operons of Escherichia coli by leucine-responsive regulatory protein.

Authors:  E Tchetina; E B Newman
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

Review 4.  The leucine-responsive regulatory protein: more than a regulator?

Authors:  R D'Ari; R T Lin; E B Newman
Journal:  Trends Biochem Sci       Date:  1993-07       Impact factor: 13.807

5.  A consensus sequence for binding of Lrp to DNA.

Authors:  Y Cui; Q Wang; G D Stormo; J M Calvo
Journal:  J Bacteriol       Date:  1995-09       Impact factor: 3.490

6.  Effects of nutrition and growth rate on Lrp levels in Escherichia coli.

Authors:  J R Landgraf; J Wu; J M Calvo
Journal:  J Bacteriol       Date:  1996-12       Impact factor: 3.490

7.  Use of an in vivo titration method to study a global regulator: effect of varying Lrp levels on expression of gltBDF in Escherichia coli.

Authors:  D W Borst; R M Blumenthal; R G Matthews
Journal:  J Bacteriol       Date:  1996-12       Impact factor: 3.490

Review 8.  The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli.

Authors:  J M Calvo; R G Matthews
Journal:  Microbiol Rev       Date:  1994-09

9.  Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids.

Authors:  B M Prüss; J M Nelms; C Park; A J Wolfe
Journal:  J Bacteriol       Date:  1994-04       Impact factor: 3.490

Review 10.  Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli.

Authors:  E B Newman; R Lin
Journal:  Annu Rev Microbiol       Date:  1995       Impact factor: 15.500
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  6 in total

1.  Influence of L-leucine and L-alanine on Lrp regulation of foo, coding for F1651, a Pap homologue.

Authors:  Frédéric Berthiaume; Cécile Crost; Vincent Labrie; Christine Martin; Elaine B Newman; Josée Harel
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

2.  The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter.

Authors:  Sergio B Socías; Paula A Vincent; Raúl A Salomón
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490

Review 3.  Progress in the microbial production of S-adenosyl-L-methionine.

Authors:  Hailong Chen; Zhilai Wang; Haibo Cai; Changlin Zhou
Journal:  World J Microbiol Biotechnol       Date:  2016-07-27       Impact factor: 3.312

4.  Two roles for the leucine-responsive regulatory protein in expression of the alanine catabolic operon (dadAB) in Klebsiella aerogenes.

Authors:  B K Janes; R A Bender
Journal:  J Bacteriol       Date:  1999-02       Impact factor: 3.490

Review 5.  Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective.

Authors:  Wally C van Heeswijk; Hans V Westerhoff; Fred C Boogerd
Journal:  Microbiol Mol Biol Rev       Date:  2013-12       Impact factor: 11.056

6.  Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio.

Authors:  Robert E Lintner; Pankaj K Mishra; Poonam Srivastava; Betsy M Martinez-Vaz; Arkady B Khodursky; Robert M Blumenthal
Journal:  BMC Microbiol       Date:  2008-04-11       Impact factor: 3.605
  6 in total

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