Literature DB >> 8561478

Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli.

E B Newman1, R Lin.   

Abstract

The leucine-responsive regulatory protein (Lrp) regulates transcription of the many genes of the Lrp regulon, repressing some and activating others, some in response to L-leucine and some independent of it. The physiology and molecular biology of the regulon in Escherichia coli are summarized here. However, the high degree of conservation of the protein suggests that it has an important role in all enterobacteria. We suggest that this role is not only as a transcriptional regulator but also as a determinant of chromosome structure.

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Year:  1995        PMID： 8561478     DOI： 10.1146/annurev.mi.49.100195.003531

Source DB:  PubMed          Journal:  Annu Rev Microbiol        ISSN： 0066-4227            Impact factor:   15.500


  69 in total

1.  Bacillus subtilis LrpC is a sequence-independent DNA-binding and DNA-bending protein which bridges DNA.

Authors:  A Tapias; G López; S Ayora
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

2.  Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus.

Authors:  P M Leonard; S H Smits; S E Sedelnikova; A B Brinkman; W M de Vos; J van der Oost; D W Rice; J B Rafferty
Journal:  EMBO J       Date:  2001-03-01       Impact factor: 11.598

3.  A thermostable platform for transcriptional regulation: the DNA-binding properties of two Lrp homologs from the hyperthermophilic archaeon Methanococcus jannaschii.

Authors:  M Ouhammouch; E P Geiduschek
Journal:  EMBO J       Date:  2001-01-15       Impact factor: 11.598

4.  A Pyrococcus homolog of the leucine-responsive regulatory protein, LrpA, inhibits transcription by abrogating RNA polymerase recruitment.

Authors:  Isabell Dahlke; Michael Thomm
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

5.  The high-mobility group A-type protein CarD of the bacterium Myxococcus xanthus as a transcription factor for several distinct vegetative genes.

Authors:  Marisa Galbis-Martínez; Marta Fontes; Francisco J Murillo
Journal:  Genetics       Date:  2004-08       Impact factor: 4.562

6.  The archaeal feast/famine regulatory protein: potential roles of its assembly forms for regulating transcription.

Authors:  Hideaki Koike; Sanae A Ishijima; Lester Clowney; Masashi Suzuki
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-19       Impact factor: 11.205

7.  The TonB3 system in the human pathogen Vibrio vulnificus is under the control of the global regulators Lrp and cyclic AMP receptor protein.

Authors:  Alejandro F Alice; Jorge H Crosa
Journal:  J Bacteriol       Date:  2012-02-03       Impact factor: 3.490

8.  Modulation of the sensitivity of FimB recombination to branched-chain amino acids and alanine in Escherichia coli K-12.

Authors:  Maryam Lahooti; Paula L Roesch; Ian C Blomfield
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490

9.  Structure of the Escherichia coli leucine-responsive regulatory protein Lrp reveals a novel octameric assembly.

Authors:  Stephanie de los Rios; John J Perona
Journal:  J Mol Biol       Date:  2006-12-19       Impact factor: 5.469

10.  The leucine-responsive regulatory protein, Lrp, activates transcription of the fim operon in Salmonella enterica serovar typhimurium via the fimZ regulatory gene.

Authors:  Kirsty A McFarland; Sacha Lucchini; Jay C D Hinton; Charles J Dorman
Journal:  J Bacteriol       Date:  2007-11-02       Impact factor: 3.490
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