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Literature DB >> 934360

Inhibition of the reuptake of serotonin by tryptoline.

H Rommelspacher, P Bade, H Coper, G Kossmehl.

Abstract

Tryptoline, a metabolite of tryptamine, competitively inhibits serotonin accumulation in nuclei-free homogenate of rat "forebrains". After intraventricular injection the drug elicits an increase of serotonin levels in the same part of the brain whereas the monoamine oxidase activity is not altered.

Entities: Chemical Species

Mesh：

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Year: 1976 PMID： 934360 DOI： 10.1007/bf00506495

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

14 in total

1. A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.

Authors: R J WURTMAN; J AXELROD
Journal: Biochem Pharmacol Date: 1963-12 Impact factor: 5.858

2. Synthetic experiments in the group of hypotensive alkaloids. XXI.Chemistry of 1,2,3,4- tetrahydronorharmane-1-carboxylic acid and derivatives.

Authors: Z J VEJDELEK; V TRCKA; M PROTIVA
Journal: J Med Pharm Chem Date: 1961-05-18

3. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake.

Authors: M J Kuhar; R H Roth; G K Aghajanian
Journal: J Pharmacol Exp Ther Date: 1972-04 Impact factor: 4.030

4. Action of hemicholinium-3 on cholinergic nerve terminals after alteration of neuronal impulse flow.

Authors: H Rommelspacher; A M Goldberg; M J Kuhar
Journal: Neuropharmacology Date: 1974-11 Impact factor: 5.250

5. Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slices.

Authors: A Carlsson
Journal: J Pharm Pharmacol Date: 1970-10 Impact factor: 3.765

6. Conjoint native and orthophthaldialdehyde-condensate assays for the fluorimetric determination of 5-hydroxyindoles in brain.

Authors: C Atack; M Lindqvist
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

7. 5-hydroxytryptamine uptake by rat brain in vitro.

Authors: K J Blackburn; P C French; R J Merrills
Journal: Life Sci Date: 1967-08-01 Impact factor: 5.037

8. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

Authors: E G Shaskan; S H Snyder
Journal: J Pharmacol Exp Ther Date: 1970-11 Impact factor: 4.030

9. Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain.

Authors: S B Ross; A L Renyi
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1975

Inhibition of the reuptake of serotonin by tryptoline.

1. A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE.

2. Synthetic experiments in the group of hypotensive alkaloids. XXI.Chemistry of 1,2,3,4- tetrahydronorharmane-1-carboxylic acid and derivatives.

3. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake.

4. Action of hemicholinium-3 on cholinergic nerve terminals after alteration of neuronal impulse flow.

5. Structural specificity for inhibition of [14C]-5-hydroxytryptamine uptake by cerebral slices.

6. Conjoint native and orthophthaldialdehyde-condensate assays for the fluorimetric determination of 5-hydroxyindoles in brain.

7. 5-hydroxytryptamine uptake by rat brain in vitro.

8. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.

9. Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain.

10. 5-methyltetrahydrofolic Acid as a mediator in the formation of pyridoindoles.

1. Identification of harman in the rat arcuate nucleus.

2. Tetrahydronorharmane (tetrahydro-beta-carboline), a physiologically occurring compound of indole metabolism.

3. Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo.

4. Algicidal Activity of Streptomyces eurocidicus JXJ-0089 Metabolites and Their Effects on Microcystis Physiology.