Literature DB >> 17792267

5-methyltetrahydrofolic Acid as a mediator in the formation of pyridoindoles.

L R Mandel, A Rosegay, R W Walker, W J Vandenheuvel, J Rokach.   

Abstract

Enzymes from chick and rat tissues catalyze the reaction of N-methyl tryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4b] indole. N,N-Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1H-pyrido[3,4b] indole and not N-methyltryptamine. These pyridoindoles were not formed when S-adenosylmethionine was cosubstrare.

Entities:  

Year:  1974        PMID： 17792267     DOI： 10.1126/science.186.4165.741

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Inhibition of the reuptake of serotonin by tryptoline.

Authors:  H Rommelspacher; P Bade; H Coper; G Kossmehl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

2.  6-Hydroxy-tetrahydronorharmane (6-hydroxy-tetrahydro-beta-carboline), a new active metabolite of indole-alkylamines in man and rat.

Authors:  H Rommelspacher; H Honecker; M Barbey; B Meinke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

3.  Neurochemical investigations of the interaction of N,N-dimethyltryptamine with dopaminergic system in rat brain.

Authors:  P C Waldmeier; L Maître
Journal:  Psychopharmacology (Berl)       Date:  1977-04-29       Impact factor: 4.530

4.  Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

Authors:  C Braestrup; M Nielsen; C E Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

5.  Endocrine effects of 5-methoxytryptoline, 5-hydroxytryptoline and tryptoline, putative modulators of rat serotonergic system.

Authors:  A C Rovescalli; N Brunello; G Racagni
Journal:  J Endocrinol Invest       Date:  1987-02       Impact factor: 4.256

6.  Tetrahydronorharmane (tetrahydro-beta-carboline), a physiologically occurring compound of indole metabolism.

Authors:  H Honecker; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-11       Impact factor: 3.000

7.  Inhibition of 5-hydroxytryptamine uptake by tetrahydronorharmane in vivo.

Authors:  H Rommelspacher; S Strauss; C H Cohnitz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-07       Impact factor: 3.000
  7 in total

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