Literature DB >> 732889

Tetrahydronorharmane (tetrahydro-beta-carboline), a physiologically occurring compound of indole metabolism.

H Honecker, H Rommelspacher.   

Abstract

In the present paper a sensitive method is described to measure tetrahydronorharmane (THN) in the urine of man and rats as well as in the forebrain of rats. The compound is extracted into diethyl ether, separated by thin layer chromatography (TLC), acetylated with radiolabelled acetic anhydride and further isolated by two-dimensional TLC development. The existence of THN in urine of man was proven by using chromatography with different solvent systems, cocristallisation, isotope dilution technique as well as mass-spectrometry. The amount of THN in the urine varied over a wide range. With the same method it was demonstrated that THN occurs also in the forebrain of rats. The concentration increases after loading with tryptamine. The findings are discussed in view of the hypothesis that THN acts as a compound modulating neuronal mechanism.

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Year:  1978        PMID： 732889     DOI： 10.1007/bf00508283

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  16 in total

Review 1.  Alkaloid products in the metabolism of alcohol and biogenic amines.

Authors:  G Cohen
Journal:  Biochem Pharmacol       Date:  1976-05-15       Impact factor: 5.858

2.  Identification of alkaloids; the condensation products of biogenic amines with formaldehyde, enzymatically formed from 5-methyltetrahydrofolic acid.

Authors:  W Lauwers; J Leysen; H Verhoeven; P Laduron
Journal:  Biomed Mass Spectrom       Date:  1975-02

3.  Synthetic experiments in the group of hypotensive alkaloids. XXI.Chemistry of 1,2,3,4- tetrahydronorharmane-1-carboxylic acid and derivatives.

Authors:  Z J VEJDELEK; V TRCKA; M PROTIVA
Journal:  J Med Pharm Chem       Date:  1961-05-18

4.  5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.

Authors:  E Meller; H Rosengarten; A J Friedhoff; R D Stebbins; R Silber
Journal:  Science       Date:  1975-01-17       Impact factor: 47.728

5.  On the mode of formation of tetrahydro-beta carbolines.

Authors:  H Rommelspacher; H Coper; S Strauss
Journal:  Life Sci       Date:  1976-01-01       Impact factor: 5.037

6.  Tetrahydro-beta-carbolines: specific inhibitors of type A monoamine oxidase in rat brain.

Authors:  E Meller; E Friedman; J W Schweitzer; A J Friedhoff
Journal:  J Neurochem       Date:  1977-05       Impact factor: 5.372

7.  Inhibition of the reuptake of serotonin by tryptoline.

Authors:  H Rommelspacher; P Bade; H Coper; G Kossmehl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

8.  Alkaloid content of Banisteriopsis rusbyana.

Authors:  S Agurell; B Holmstedt; J E Lindgren
Journal:  Am J Pharm Sci Support Public Health       Date:  1968 Sep-Oct

9.  An acetaldehyde artifact in studies of the interaction of ethanol with biogenic amine systems: the oxidation of ethanol by ascorbic acid.

Authors:  G Cohen
Journal:  J Neurochem       Date:  1977-10       Impact factor: 5.372

10.  Pharmacological properties of tetrahydronorharmane (tryptoline).

Authors:  H Rommelspacher; H Kauffmann; C H Cohnitz; H Coper
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-06       Impact factor: 3.000
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  11 in total

1.  Brain serotonin and 5-hydroxyindoleacetic acid concentrations and serotonin synthesis following tetrahydro-beta-carboline administration in mice.

Authors:  N S Buckholtz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-11       Impact factor: 3.000

2.  6-Hydroxy-tetrahydronorharmane (6-hydroxy-tetrahydro-beta-carboline), a new active metabolite of indole-alkylamines in man and rat.

Authors:  H Rommelspacher; H Honecker; M Barbey; B Meinke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

3.  Output of endogenous monoamine oxidase inhibitor in rats: effect of ethanol, tryptamine and tryptophan.

Authors:  I Armando; V Glover; M Sandler; S E File
Journal:  J Neural Transm       Date:  1983       Impact factor: 3.575

4.  Identification of harman in the rat arcuate nucleus.

Authors:  D W Shoemaker; J T Cummins; T G Bidder; H G Boettger; M Evans
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-01       Impact factor: 3.000

5.  In vivo formation of histamine phosphopyridoxal cyclic compounds.

Authors:  D Kierska; K Sasiak; C Maśliński
Journal:  Agents Actions       Date:  1981-04

6.  1-Methyl-beta-carboline (harmane), a potent endogenous inhibitor of benzodiazepine receptor binding.

Authors:  H Rommelspacher; C Nanz; H O Borbe; K J Fehske; W E Müller; U Wollert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

7.  Endocrine effects of 5-methoxytryptoline, 5-hydroxytryptoline and tryptoline, putative modulators of rat serotonergic system.

Authors:  A C Rovescalli; N Brunello; G Racagni
Journal:  J Endocrinol Invest       Date:  1987-02       Impact factor: 4.256

8.  Two metabolic pathways of tetrahydronorharmane (tetrahydro-beta-carboline) in rats.

Authors:  B Greiner; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-04       Impact factor: 3.000

9.  Pharmacokinetics of tetrahydronorharmane (tetrahydro-beta-carboline) in rats.

Authors:  B Greiner; C Fähndrich; S Strauss; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

10.  Formation of a beta-carboline (1,2,3,4-tetrahydro-1-methyl-beta-carboline-1-carboxylic acid) following intracerebroventricular injection of tryptamine and pyruvic acid.

Authors:  R Susilo; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-01       Impact factor: 3.000
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