Literature DB >> 7374793

Identification of harman in the rat arcuate nucleus.

D W Shoemaker, J T Cummins, T G Bidder, H G Boettger, M Evans.   

Abstract

This communication describes the presence of 1-methyl-beta-carboline (harman) in the hypophysiotropic area of the hypothalamus which incorporates the arcuate nucleus. Diethyl ether extracts of borate-buffered arcuate homogenates were subjected to silica column chromatography and thin-layer chromatography (TLC). Identification of the beta-carboline was accomplished by use of fluorescent spectrometry, gas chromatography (GC), mass spectrometry (MS) and combined gas chromatography-mass spectrometry (GC-MS).

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Year:  1980        PMID： 7374793     DOI： 10.1007/bf00499914

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  30 in total

1.  EXPERIENCES WITH PRIMARY PROCESS THINKING.

Authors:  W J TURNER
Journal:  Psychiatr Q       Date:  1963-07

2.  On the mode of formation of tetrahydro-beta carbolines.

Authors:  H Rommelspacher; H Coper; S Strauss
Journal:  Life Sci       Date:  1976-01-01       Impact factor: 5.037

3.  Adrenocorticotropin in rat brain: immunocytochemical localization in cells and axons.

Authors:  S J Watson; C W Richard; J D Barchas
Journal:  Science       Date:  1978-06-09       Impact factor: 47.728

4.  Formation of 1,2,3,4,-tetrahydro-beta-carboline and methylene-beta-phenylethylimine from 5-methyltetrahydrofolate and amines in tissues from developing rat brain.

Authors:  L L Hsu
Journal:  Life Sci       Date:  1976-08-15       Impact factor: 5.037

Review 5.  Aspects of hypothalamic regulation of the pituitary gland.

Authors:  A V Schally
Journal:  Science       Date:  1978-10-06       Impact factor: 47.728

6.  Inhibition of the reuptake of serotonin by tryptoline.

Authors:  H Rommelspacher; P Bade; H Coper; G Kossmehl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

7.  The mode of action of 6-methoxy-1,2,3,4-tetrahydro- -carboline on brain serotonin.

Authors:  B T Ho; D Taylor; K E Walker; W M McIsaac
Journal:  Can J Biochem       Date:  1973-04

8.  Structure-activity relationships for the reserpine-like actions of derivatives of beta-carboline in vitro.

Authors:  T A Slotkin
Journal:  Life Sci       Date:  1974-08-01       Impact factor: 5.037

9.  Topography of the neurons responding to estrogen in the hypothalamic arcuate nucleus of immature female mice.

Authors:  M Nishizuka
Journal:  Brain Res       Date:  1978-08-18       Impact factor: 3.252

10.  Structure-action relationship of beta-carbolines as monoamine oxidase inhibitors.

Authors:  W M McIsaac; V Estevez
Journal:  Biochem Pharmacol       Date:  1966-10       Impact factor: 5.858
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  10 in total

1.  Characterization of brain beta-carboline-2-N-methyltransferase, an enzyme that may play a role in idiopathic Parkinson's disease.

Authors:  D A Gearhart; E J Neafsey; M A Collins
Journal:  Neurochem Res       Date:  1997-02       Impact factor: 3.996

2.  5-HT, dopamine, norepinephrine, and related metabolites in brain of low alcohol drinking (LAD) rats shift after chronic intra-hippocampal infusion of harman.

Authors:  A Adell; R D Myers
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996

3.  Comparison of the in vitro binding characteristics of the beta-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla.

Authors:  T May; A Greube; S Strauss; D Heineke; J Lehmann; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-03       Impact factor: 3.000

4.  1-Methyl-beta-carboline (harmane), a potent endogenous inhibitor of benzodiazepine receptor binding.

Authors:  H Rommelspacher; C Nanz; H O Borbe; K J Fehske; W E Müller; U Wollert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-10       Impact factor: 3.000

5.  Lack of specificity in cation effects on solubilized benzodiazepine receptor.

Authors:  S Mizuno; N Ogawa; A Mori
Journal:  Neurochem Res       Date:  1984-12       Impact factor: 3.996

6.  Formation of 1-methyl-beta-carbolines in rats from their possible carboxylic acid precursor.

Authors:  R Susilo; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-05       Impact factor: 3.000

7.  Pharmacokinetics of tetrahydronorharmane (tetrahydro-beta-carboline) in rats.

Authors:  B Greiner; C Fähndrich; S Strauss; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

8.  Ethanol induces an increase of harman in the brain and urine of rats.

Authors:  H Rommelspacher; H Damm; S Strauss; G Schmidt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-09       Impact factor: 3.000

9.  Formation of a beta-carboline (1,2,3,4-tetrahydro-1-methyl-beta-carboline-1-carboxylic acid) following intracerebroventricular injection of tryptamine and pyruvic acid.

Authors:  R Susilo; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-01       Impact factor: 3.000

10.  beta-Carbolines as selective monoamine oxidase inhibitors: in vivo implications.

Authors:  V Glover; J Liebowitz; I Armando; M Sandler
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575
  10 in total

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