Literature DB >> 934343

Model consideration for the origin of life. Environmental structure as stimulus for the evolution of chemical systems.

H Kuhn.   

Abstract

In an attempt to understand the origin of living systems we encounter the following problems: How can we conceive the origin of the first self-reproducing forms, and by means of what stimuli could a constant increase in the complexity of such forms commence? How can a translation apparatus for genetic information develop? One cannot imagine that such an apparatus for the synthesis of enzymes can function alone without the interference of enzymes themselves, which, however, could only become available after the construction of the apparatus itself. What stimulus mechanism is conceivable that leads to the division of the genetic apparatus into a replication system, and an enzyme-synthesis system? The main problem therefore, is not the search for basic theoretical concepts. It is not a question which can be answered by means of specific experiments. One should rather explore the principal possibilities of how molecules combine to produce more and more complicated functional units. We look for the fundamental structural changes in the organizational systems and the driving forces initiating these developments. Questions concerning the detailed chemical realization are of secondary importance. In trying to solve the puzzle of how the genetic apparatus is gradually built up as complex aggregates of molecules, we consider a consistent causal chain of simple and transparent physiochemical model steps. The driving force for the self-organization of matter is seen in a specific environmental structure to be found on the surface of the earth. By this structure, which is periodic in time and heterogeneous in space, evolution is initiated and driven towards a continuously increasing degree of complexity correlated with a continuous expansion of the accessible living space. This process is a necessity under proper environmental conditions. Accidental events initiate each step but do not determine the general course of evolution which is determined by the selection mechanism.

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Year:  1976        PMID: 934343     DOI: 10.1007/bf00622405

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN: 0028-1042


  8 in total

1.  Carriers and specificity in membranes. VI. Biological flow structure and their relation to chemicodiffusional coupling.

Authors:  A Katchalsky
Journal:  Neurosci Res Program Bull       Date:  1971-06

2.  Self-ordered polymers and propagative cell-like systems.

Authors:  S W Fox
Journal:  Naturwissenschaften       Date:  1969-01

3.  Prebiotic synthesis of polypeptides by heterogeneous polycondensation of amino-acid adenylates.

Authors:  M Paecht-Horowitz; J Berger; A Katchalsky
Journal:  Nature       Date:  1970-11-14       Impact factor: 49.962

4.  Non-Darwinian evolution.

Authors:  J L King; T H Jukes
Journal:  Science       Date:  1969-05-16       Impact factor: 47.728

Review 5.  Self-organization of molecular systems and evolution of the genetic apparatus.

Authors:  H Kuhn
Journal:  Angew Chem Int Ed Engl       Date:  1972-09       Impact factor: 15.336

Review 6.  Selforganization of matter and the evolution of biological macromolecules.

Authors:  M Eigen
Journal:  Naturwissenschaften       Date:  1971-10

7.  Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain.

Authors:  S H Kim; G J Quigley; F L Suddath; A McPherson; D Sneden; J J Kim; J Weinzierl; A Rich
Journal:  Science       Date:  1973-01-19       Impact factor: 47.728

8.  Evidence for de novo production of self-replicating and environmentally adapted RNA structures by bacteriophage Qbeta replicase.

Authors:  M Sumper; R Luce
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

  8 in total
  15 in total

1.  Computer-modeling origin of a simple genetic apparatus.

Authors:  C Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

2.  Extreme accumulation of nucleotides in simulated hydrothermal pore systems.

Authors:  Philipp Baaske; Franz M Weinert; Stefan Duhr; Kono H Lemke; Michael J Russell; Dieter Braun
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-09       Impact factor: 11.205

Review 3.  Darwin's warm little pond revisited: from molecules to the origin of life.

Authors:  Hartmut Follmann; Carol Brownson
Journal:  Naturwissenschaften       Date:  2009-09-17

4.  An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation.

Authors:  Christoph Kuhn
Journal:  J Mol Model       Date:  2011-05-11       Impact factor: 1.810

Review 5.  Exon-intron-like pattern of the first propagating molecule?

Authors:  N Lahav
Journal:  J Mol Evol       Date:  1989-12       Impact factor: 2.395

6.  Biotin. Its place in evolution.

Authors:  C M Visser; R M Kellogg
Journal:  J Mol Evol       Date:  1978-06-20       Impact factor: 2.395

7.  Evolution of a genetic code simulated with the computer.

Authors:  H Kuhn; C Kuhn
Journal:  Orig Life       Date:  1978-12

8.  The synthesis of primitive 'living' forms: definitions, goals, strategies and evolution synthesizers.

Authors:  N Lahav
Journal:  Orig Life Evol Biosph       Date:  1985       Impact factor: 1.950

9.  Steps towards the formation of a protocell: the possible role of short peptides.

Authors:  Maya Fishkis
Journal:  Orig Life Evol Biosph       Date:  2007-09-14       Impact factor: 1.950

10.  Lipid-assisted synthesis of RNA-like polymers from mononucleotides.

Authors:  Sudha Rajamani; Alexander Vlassov; Seico Benner; Amy Coombs; Felix Olasagasti; David Deamer
Journal:  Orig Life Evol Biosph       Date:  2007-11-16       Impact factor: 1.950

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