Literature DB >> 21559961

An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation.

Christoph Kuhn1.   

Abstract

The concept called Knowledge is a measure of the quality of genetically transferred information. Its usefulness is demonstrated quantitatively in a Monte-Carlo simulation on critical steps in a origin of life model. The model describes the origin of a bio-like genetic apparatus by a long sequence of physical-chemical steps: it starts with the presence of a self-replicating oligomer and a specifically structured environment in time and space that allow for the formation of aggregates such as assembler-hairpins-devices and, at a later stage, an assembler-hairpins-enzyme device-a first translation machine.

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Year:  2011        PMID: 21559961      PMCID: PMC3267034          DOI: 10.1007/s00894-011-1081-9

Source DB:  PubMed          Journal:  J Mol Model        ISSN: 0948-5023            Impact factor:   1.810


  12 in total

1.  Synthesizing life.

Authors:  J W Szostak; D P Bartel; P L Luisi
Journal:  Nature       Date:  2001-01-18       Impact factor: 49.962

2.  Computer-modeling origin of a simple genetic apparatus.

Authors:  C Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 3.  The roads to and from the RNA world.

Authors:  Jason P Dworkin; Antonio Lazcano; Stanley L Miller
Journal:  J Theor Biol       Date:  2003-05-07       Impact factor: 2.691

4.  Model consideration for the origin of life. Environmental structure as stimulus for the evolution of chemical systems.

Authors:  H Kuhn
Journal:  Naturwissenschaften       Date:  1976-02

5.  A computer-glimpse of the origin of life.

Authors:  Christoph Kuhn
Journal:  J Biol Phys       Date:  2005-12       Impact factor: 1.365

6.  Central dogma of molecular biology.

Authors:  F Crick
Journal:  Nature       Date:  1970-08-08       Impact factor: 49.962

Review 7.  Self-organization of molecular systems and evolution of the genetic apparatus.

Authors:  H Kuhn
Journal:  Angew Chem Int Ed Engl       Date:  1972-09       Impact factor: 15.336

8.  Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions.

Authors:  Matthew W Powner; Béatrice Gerland; John D Sutherland
Journal:  Nature       Date:  2009-05-14       Impact factor: 49.962

Review 9.  Prebiotic chemistry and the origin of the RNA world.

Authors:  Leslie E Orgel
Journal:  Crit Rev Biochem Mol Biol       Date:  2004 Mar-Apr       Impact factor: 8.250

10.  Selection and evolution of enzymes from a partially randomized non-catalytic scaffold.

Authors:  Burckhard Seelig; Jack W Szostak
Journal:  Nature       Date:  2007-08-16       Impact factor: 49.962

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  1 in total

1.  Immune response to a variable pathogen: a stochastic model with two interlocked Darwinian entities.

Authors:  Christoph Kuhn
Journal:  Comput Math Methods Med       Date:  2012-12-02       Impact factor: 2.238

  1 in total

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