Literature DB >> 752134

Evolution of a genetic code simulated with the computer.

H Kuhn, C Kuhn.   

Abstract

A simple selforganizing model system of molecules is considered and it is demonstrated by a computer simulation, that a genetic code of 16 elements (aminoacids) can gradually be formed by such a system in the course of many generations. By a number of rare chance events, each suppressing other events of equal a priori probability, a single code results out of an immense number of possible codes of the same a priori probability. The result is discussed in relation to the uniqueness of the genetic code in living systems. The computer simulation emphasizes a particular step in a model pathway discussed elsewhere consisting of many assumed physicochemical steps leading to a genetic apparatus.

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Year:  1978        PMID: 752134     DOI: 10.1007/bf00931411

Source DB:  PubMed          Journal:  Orig Life        ISSN: 0302-1688


  7 in total

1.  A speculation on the origin of protein synthesis.

Authors:  F H Crick; S Brenner; A Klug; G Pieczenik
Journal:  Orig Life       Date:  1976-12

2.  Model consideration for the origin of life. Environmental structure as stimulus for the evolution of chemical systems.

Authors:  H Kuhn
Journal:  Naturwissenschaften       Date:  1976-02

3.  Self-ordered polymers and propagative cell-like systems.

Authors:  S W Fox
Journal:  Naturwissenschaften       Date:  1969-01

Review 4.  Self-organization of molecular systems and evolution of the genetic apparatus.

Authors:  H Kuhn
Journal:  Angew Chem Int Ed Engl       Date:  1972-09       Impact factor: 15.336

5.  Computer model of the formation of self-organizing systems.

Authors:  H D Försterling; H Kuhn; K H Tews
Journal:  Angew Chem Int Ed Engl       Date:  1972-09       Impact factor: 15.336

Review 6.  Selforganization of matter and the evolution of biological macromolecules.

Authors:  M Eigen
Journal:  Naturwissenschaften       Date:  1971-10

7.  The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.

Authors:  M Eigen; P Schuster
Journal:  Naturwissenschaften       Date:  1977-11
  7 in total
  6 in total

1.  Computer-modeling origin of a simple genetic apparatus.

Authors:  C Kuhn
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

2.  Self-organization in prebiological systems: simulations of a model for the origin of genetic information.

Authors:  D S Rokhsar; P W Anderson; D L Stein
Journal:  J Mol Evol       Date:  1986       Impact factor: 2.395

3.  A model of autocatalytic replication.

Authors:  L F Abbott
Journal:  J Mol Evol       Date:  1988       Impact factor: 2.395

Review 4.  Partition of aminoacyl-tRNA synthetases in two different structural classes dating back to early metabolism: implications for the origin of the genetic code and the nature of protein sequences.

Authors:  M Delarue
Journal:  J Mol Evol       Date:  1995-12       Impact factor: 2.395

5.  Model approach of the breakthrough of a translation machine and the origin of the genetic code.

Authors:  U Lehmann; H Kuhn
Journal:  Orig Life       Date:  1984

6.  Ambiguity and the evolution of the genetic code.

Authors:  R R Kocherlakota; N D Acland
Journal:  Orig Life       Date:  1982-03
  6 in total

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