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Literature DB >> 9195994

High-resolution mapping by YAC fragmentation of a 2.5-Mb Xp22 region containing the human RS, KFSD and CLS disease genes.

E Van de Vosse¹, P Van der Bent, J J Heus, G J Van Ommen, J T Den Dunnen.

Abstract

The disease loci for X-linked Retinoschisis (RS), Keratosis follicularis spinulosa decalvans (KFSD), and Coffin-Lowry syndrome (CLS) have been localized to the same, small region in Xp22 on the human X Chromosome (Chr). To generate a high-resolution map of the available contig in this area, we have used the YAC fragmentation vectors pBP108/ADE2 and pBP109/ADE2 and generated fragmented YACs from a 2.5-Mb YAC (y939H7) spanning the mentioned disease gene candidate regions. Forty-seven fragmented YACs were generated and analyzed, ranging in size from 170 kb to over 2400 kb. The resulting YAC fragmentation panel was used to construct a detailed restriction map of the region and has been used to bin clones and markers. As a deletion panel, it will present a valuable resource for further mapping.

Entities: Disease Gene Species

Mesh：

Substances：
Genetic Markers

Year: 1997 PMID： 9195994 DOI： 10.1007/s003359900483

Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957

23 in total

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Authors: L Huopaniemi; A Rantala; E Tahvanainen; A de la Chapelle; T Alitalo
Journal: Am J Hum Genet Date: 1997-05 Impact factor: 11.025

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Journal: Nucleic Acids Res Date: 1996-03-15 Impact factor: 16.971

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Journal: Nature Date: 1996-03-14 Impact factor: 49.962

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Journal: Hum Genet Date: 1996-01 Impact factor: 4.132

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Authors: E Van De Vosse; P F Booms; R H Vossen; M C Wapenaar; G J Van Ommen; J T Den Dunnen
Journal: Hum Mol Genet Date: 1993-12 Impact factor: 6.150

7. Nance-Horan syndrome: linkage analysis in a family from The Netherlands.

Authors: A A Bergen; J ten Brink; E J Schuurman; E M Bleeker-Wagemakers
Journal: Genomics Date: 1994-05-01 Impact factor: 5.736

8. A high resolution deletion map of human chromosome Xp22.

Authors: L Schaefer; G B Ferrero; A Grillo; M T Bassi; E J Roth; M C Wapenaar; G J van Ommen; T K Mohandas; M Rocchi; H Y Zoghbi; A Ballabio
Journal: Nat Genet Date: 1993-07 Impact factor: 38.330

9. Refinement of the localisation of the X linked keratosis follicularis spinulosa decalvans (KFSD) gene in Xp22.13-p22.2.

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Journal: J Med Genet Date: 1995-09 Impact factor: 6.318