Literature DB >> 8557262

Construction of a YAC contig and an STS map spanning 3.6 megabase pairs in Xp22.1.

D Trump1, G Pilia, P H Dixon, C Wooding, R Thakrar, S E Leigh, R Nagaraja, M P Whyte, D Schlessinger, R V Thakker.   

Abstract

We have constructed a 3.6 Mb sequence tagged sites (STS)-based yeast artificial chromosome (YAC) contig, consisting of 58 individual YAC clones, spanning the region PDHA1 and DXS451 on Xp22.1. In addition to establishing the order of PDHA1, ISPK-1, DXS2504, DXS1528 and the 13 known polymorphic loci as Xpter-PDHA1-DXS443-DXS3424-ISPK-1-DXS12 29-DXS2504-DXS1528-DXS365-DXS7101- DXS1683-DXS1052-DXS274-DXS92-DXS1226-DX S41-DXS989-DXS451-Xcen, we have also developed 35 novel STSs from YAC end clones. These results provide a high density of STS markers (approximately 1 per 70 kb). Furthermore, a detailed long-range restriction map of the contig has been constructed with rare-cutter enzymes and this has refined and verified the physical distances between markers inferred from YAC sizes and their STS content. The integration of the physical mapping data with previous genetic mapping data and the use of STSs and non-chimeric YAC clones reported here should facilitate the construction of a transcript map of this region and the positional cloning of disease genes in this portion of Xp22.1.

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Year:  1996        PMID： 8557262     DOI： 10.1007/bf00218834

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  37 in total

1.  Linkage analysis of two cloned DNA sequences, DXS197 and DXS207, in hypophosphatemic rickets families.

Authors:  R V Thakker; K E Davies; A P Read; P Tippett; C Wooding; T Flint; S Wood; T A Kruse; M P Whyte; J L O'Riordan
Journal:  Genomics       Date:  1990-10       Impact factor: 5.736

2.  A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones.

Authors:  J Riley; R Butler; D Ogilvie; R Finniear; D Jenner; S Powell; R Anand; J C Smith; A F Markham
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

3.  X-linked mental retardation with dystonic movements of the hands.

Authors:  M W Partington; J C Mulley; G R Sutherland; A Hockey; A Thode; G Turner
Journal:  Am J Med Genet       Date:  1988 May-Jun

4.  Report and abstracts of the Fifth International Workshop on Human X Chromosome Mapping 1994. Heidelberg, Germany, April 24-27, 1994.

Authors:  H F Willard; F Cremers; J L Mandel; A P Monaco; D L Nelson; D Schlessinger
Journal:  Cytogenet Cell Genet       Date:  1994

5.  Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids.

Authors:  P Wieacker; K E Davies; H J Cooke; P L Pearson; R Williamson; S Bhattacharya; J Zimmer; H H Ropers
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

6.  Mapping the gene causing X-linked recessive nephrolithiasis to Xp11.22 by linkage studies.

Authors:  S J Scheinman; M A Pook; C Wooding; J T Pang; P A Frymoyer; R V Thakker
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808

7.  A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism.

Authors:  D B Parkinson; R V Thakker
Journal:  Nat Genet       Date:  1992-05       Impact factor: 38.330

8.  Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients.

Authors:  C Bjørbaek; T A Vik; S M Echwald; P Y Yang; H Vestergaard; J P Wang; G C Webb; K Richmond; T Hansen; R L Erikson
Journal:  Diabetes       Date:  1995-01       Impact factor: 9.461

9.  Localization of a new type of X-linked liver glycogenosis to the chromosomal region Xp22 containing the liver alpha-subunit of phosphorylase kinase (PHKA2).

Authors:  J Hendrickx; P Coucke; M C Hors-Cayla; G P Smit; Y S Shin; J Deutsch; J Smeitink; R Berger; P Lee; J Fernandes
Journal:  Genomics       Date:  1994-06       Impact factor: 5.736

10.  An electrophoretic karyotype for yeast.

Authors:  G F Carle; M V Olson
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205
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  4 in total

1.  High-resolution mapping by YAC fragmentation of a 2.5-Mb Xp22 region containing the human RS, KFSD and CLS disease genes.

Authors:  E Van de Vosse; P Van der Bent; J J Heus; G J Van Ommen; J T Den Dunnen
Journal:  Mamm Genome       Date:  1997-07       Impact factor: 2.957

2.  Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.

Authors:  J T Pang; S E Lloyd; C Wooding; B Farren; B Pottinger; B Harding; S E Leigh; M A Pook; F J Benham; G T Gillett; R T Taggart; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132

3.  An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism.

Authors:  Michael R Bowl; M Andrew Nesbit; Brian Harding; Elaine Levy; Andrew Jefferson; Emanuela Volpi; Karine Rizzoti; Robin Lovell-Badge; David Schlessinger; Michael P Whyte; Rajesh V Thakker
Journal:  J Clin Invest       Date:  2005-09-15       Impact factor: 14.808

4.  EagI and NotI linking clones from human chromosomes 11 and Xp.

Authors:  M A Pook; R Thakrar; B Pottinger; B Harding; D Porteous; V van Heyningen; J Cowell; C Jones; S Povey; K E Davies; R V Thakker
Journal:  Hum Genet       Date:  1996-06       Impact factor: 4.132
  4 in total

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