Literature DB >> 9171431

Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus.

S L Ginn1, M H Brown, R A Skurray.   

Abstract

A series of fusions to the reporter proteins alkaline phosphatase and beta-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

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Year:  1997        PMID： 9171431      PMCID： PMC179179          DOI： 10.1128/jb.179.11.3786-3789.1997

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

Review 1.  Membrane transport proteins: implications of sequence comparisons.

Authors:  J K Griffith; M E Baker; D A Rouch; M G Page; R A Skurray; I T Paulsen; K F Chater; S A Baldwin; P J Henderson
Journal:  Curr Opin Cell Biol       Date:  1992-08       Impact factor: 8.382

2.  Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.

Authors:  D A Rouch; D S Cram; D DiBerardino; T G Littlejohn; R A Skurray
Journal:  Mol Microbiol       Date:  1990-12       Impact factor: 3.501

3.  Topology of the transposon Tn10-encoded tetracycline resistance protein within the inner membrane of Escherichia coli.

Authors:  B Eckert; C F Beck
Journal:  J Biol Chem       Date:  1989-07-15       Impact factor: 5.157

4.  Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis.

Authors:  I T Paulsen; R A Skurray
Journal:  Gene       Date:  1993-02-14       Impact factor: 3.688

5.  TopPred II: an improved software for membrane protein structure predictions.

Authors:  M G Claros; G von Heijne
Journal:  Comput Appl Biosci       Date:  1994-12

6.  The tet(K) gene of plasmid pT181 of Staphylococcus aureus encodes an efflux protein that contains 14 transmembrane helices.

Authors:  G G Guay; S A Khan; D M Rothstein
Journal:  Plasmid       Date:  1993-09       Impact factor: 3.466

Review 7.  A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.

Authors:  M D Marger; M H Saier
Journal:  Trends Biochem Sci       Date:  1993-01       Impact factor: 13.807

Review 8.  The topological analysis of integral cytoplasmic membrane proteins.

Authors:  B Traxler; D Boyd; J Beckwith
Journal:  J Membr Biol       Date:  1993-02       Impact factor: 1.843

9.  Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein.

Authors:  R L Smith; J L Banks; M D Snavely; M E Maguire
Journal:  J Biol Chem       Date:  1993-07-05       Impact factor: 5.157

10.  Membrane topology of the pBR322 tetracycline resistance protein. TetA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion.

Authors:  J D Allard; K P Bertrand
Journal:  J Biol Chem       Date:  1992-09-05       Impact factor: 5.157
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  14 in total

1.  The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: mutagenesis and functional analysis of motif C.

Authors:  S L Ginn; M H Brown; R A Skurray
Journal:  J Bacteriol       Date:  2000-03       Impact factor: 3.490

2.  Twelve-transmembrane-segment (TMS) version (DeltaTMS VII-VIII) of the 14-TMS Tet(L) antibiotic resistance protein retains monovalent cation transport modes but lacks tetracycline efflux capacity.

Authors:  J Jin; A A Guffanti; C Beck; T A Krulwich
Journal:  J Bacteriol       Date:  2001-04       Impact factor: 3.490

3.  Novel topology of BfpE, a cytoplasmic membrane protein required for type IV fimbrial biogenesis in enteropathogenic Escherichia coli.

Authors:  T E Blank; M S Donnenberg
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

4.  Topology of RbsC, a membrane component of the ribose transporter, belonging to the AraH superfamily.

Authors:  Y Park; C Park
Journal:  J Bacteriol       Date:  1999-02       Impact factor: 3.490

5.  Increased overall antibiotic susceptibility in Staphylococcus aureus femAB null mutants.

Authors:  B Ling; B Berger-Bächi
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

6.  Glutamate residues located within putative transmembrane helices are essential for TetA(P)-mediated tetracycline efflux.

Authors:  R M Kennan; L M McMurry; S B Levy; J I Rood
Journal:  J Bacteriol       Date:  1997-11       Impact factor: 3.490

7.  Importance of the GP dipeptide of the antiporter motif and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L).

Authors:  Magdia De Jesus; Jie Jin; Arthur A Guffanti; Terry A Krulwich
Journal:  Biochemistry       Date:  2005-09-27       Impact factor: 3.162

8.  Tet(L) and tet(K) tetracycline-divalent metal/H+ antiporters: characterization of multiple catalytic modes and a mutagenesis approach to differences in their efflux substrate and coupling ion preferences.

Authors:  Jie Jin; Arthur A Guffanti; David H Bechhofer; Terry A Krulwich
Journal:  J Bacteriol       Date:  2002-09       Impact factor: 3.490

9.  Staphylococcus aureus Tet38 Efflux Pump Structural Modeling and Roles of Essential Residues in Drug Efflux and Host Cell Internalization.

Authors:  Q C Truong-Bolduc; Y Wang; D C Hooper
Journal:  Infect Immun       Date:  2021-04-16       Impact factor: 3.441

10.  TetL tetracycline efflux protein from Bacillus subtilis is a dimer in the membrane and in detergent solution.

Authors:  Markus Safferling; Heather Griffith; Jie Jin; Josh Sharp; Magdia De Jesus; Caroline Ng; Terry A Krulwich; Da-Neng Wang
Journal:  Biochemistry       Date:  2003-12-02       Impact factor: 3.162
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