Literature DB >> 11274128

Twelve-transmembrane-segment (TMS) version (DeltaTMS VII-VIII) of the 14-TMS Tet(L) antibiotic resistance protein retains monovalent cation transport modes but lacks tetracycline efflux capacity.

J Jin1, A A Guffanti, C Beck, T A Krulwich.   

Abstract

A "Tet(L)-12" version of Tet(L), a tetracycline efflux protein with 14 transmembrane segments (TMS), was constructed by deletion of two central TMS. Tet(L)-12 catalyzed Na+/H+ antiport and antiport with K+ as a coupling ion as well as or better than wild-type Tet(L) but exhibited no tetracycline-Me2+/H+ antiport in Escherichia coli vesicles.

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Year:  2001        PMID： 11274128      PMCID： PMC95185          DOI： 10.1128/JB.183.8.2667-2671.2001

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

Review 1.  Functions of tetracycline efflux proteins that do not involve tetracycline.

Authors:  T A Krulwich; J Jin; A A Guffanti; H Bechhofer
Journal:  J Mol Microbiol Biotechnol       Date:  2001-04

2.  The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion.

Authors:  A B Weinglass; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

Review 3.  Membrane transport proteins: implications of sequence comparisons.

Authors:  J K Griffith; M E Baker; D A Rouch; M G Page; R A Skurray; I T Paulsen; K F Chater; S A Baldwin; P J Henderson
Journal:  Curr Opin Cell Biol       Date:  1992-08       Impact factor: 8.382

Review 4.  Active efflux mechanisms for antimicrobial resistance.

Authors:  S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191

Review 5.  Efficient site-directed mutagenesis using uracil-containing DNA.

Authors:  T A Kunkel; K Bebenek; J McClary
Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

6.  Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis.

Authors:  I T Paulsen; R A Skurray
Journal:  Gene       Date:  1993-02-14       Impact factor: 3.688

7.  Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein.

Authors:  A Yamaguchi; T Udagawa; T Sawai
Journal:  J Biol Chem       Date:  1990-03-25       Impact factor: 5.157

8.  Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter system(s).

Authors:  E Padan; N Maisler; D Taglicht; R Karpel; S Schuldiner
Journal:  J Biol Chem       Date:  1989-12-05       Impact factor: 5.157

9.  Gene duplication in the evolution of the two complementing domains of gram-negative bacterial tetracycline efflux proteins.

Authors:  R A Rubin; S B Levy; R L Heinrikson; F J Kézdy
Journal:  Gene       Date:  1990-03-01       Impact factor: 3.688

10.  An N-terminal domain of the tetracycline resistance protein increases susceptibility to aminoglycosides and complements potassium uptake defects in Escherichia coli.

Authors:  J K Griffith; T Kogoma; D L Corvo; W L Anderson; A L Kazim
Journal:  J Bacteriol       Date:  1988-02       Impact factor: 3.490
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  11 in total

1.  Rapid Bioinformatic Identification of Thermostabilizing Mutations.

Authors:  David B Sauer; Nathan K Karpowich; Jin Mei Song; Da-Neng Wang
Journal:  Biophys J       Date:  2015-10-06       Impact factor: 4.033

Review 2.  Alkaline pH homeostasis in bacteria: new insights.

Authors:  Etana Padan; Eitan Bibi; Masahiro Ito; Terry A Krulwich
Journal:  Biochim Biophys Acta       Date:  2005-09-26

3.  Importance of the GP dipeptide of the antiporter motif and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L).

Authors:  Magdia De Jesus; Jie Jin; Arthur A Guffanti; Terry A Krulwich
Journal:  Biochemistry       Date:  2005-09-27       Impact factor: 3.162

4.  MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.

Authors:  Q C Truong-Bolduc; P M Dunman; J Strahilevitz; S J Projan; D C Hooper
Journal:  J Bacteriol       Date:  2005-04       Impact factor: 3.490

5.  The major facilitator superfamily (MFS) revisited.

Authors:  Vamsee S Reddy; Maksim A Shlykov; Rostislav Castillo; Eric I Sun; Milton H Saier
Journal:  FEBS J       Date:  2012-05-08       Impact factor: 5.542

6.  Site-directed mutagenesis studies of selected motif and charged residues and of cysteines of the multifunctional tetracycline efflux protein Tet(L).

Authors:  Jie Jin; Terry A Krulwich
Journal:  J Bacteriol       Date:  2002-03       Impact factor: 3.490

7.  Tet(L) and tet(K) tetracycline-divalent metal/H+ antiporters: characterization of multiple catalytic modes and a mutagenesis approach to differences in their efflux substrate and coupling ion preferences.

Authors:  Jie Jin; Arthur A Guffanti; David H Bechhofer; Terry A Krulwich
Journal:  J Bacteriol       Date:  2002-09       Impact factor: 3.490

8.  TetL tetracycline efflux protein from Bacillus subtilis is a dimer in the membrane and in detergent solution.

Authors:  Markus Safferling; Heather Griffith; Jie Jin; Josh Sharp; Magdia De Jesus; Caroline Ng; Terry A Krulwich; Da-Neng Wang
Journal:  Biochemistry       Date:  2003-12-02       Impact factor: 3.162

9.  Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane.

Authors:  Karl A Hassan; Talal Souhani; Ronald A Skurray; Melissa H Brown
Journal:  J Bacteriol       Date:  2008-01-25       Impact factor: 3.490

10.  Dissection of Protonation Sites for Antibacterial Recognition and Transport in QacA, a Multi-Drug Efflux Transporter.

Authors:  Puja Majumder; Shashank Khare; Arunabh Athreya; Nazia Hussain; Ashutosh Gulati; Aravind Penmatsa
Journal:  J Mol Biol       Date:  2019-03-23       Impact factor: 5.469
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