Literature DB >> 9559813

Increased overall antibiotic susceptibility in Staphylococcus aureus femAB null mutants.

B Ling1, B Berger-Bächi.   

Abstract

The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests that femAB null mutants are only viable because of a compensatory mutation in an unlinked site.

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Year:  1998        PMID： 9559813      PMCID： PMC105572          DOI： 10.1128/AAC.42.4.936

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Consequences of the interaction of beta-lactam antibiotics with penicillin binding proteins from sensitive and resistant Staphylococcus aureus strains.

Authors:  H Labischinski
Journal:  Med Microbiol Immunol       Date:  1992       Impact factor: 3.402

2.  Comparison of the E Test to agar dilution, broth microdilution, and agar diffusion susceptibility testing techniques by using a special challenge set of bacteria.

Authors:  C N Baker; S A Stocker; D H Culver; C Thornsberry
Journal:  J Clin Microbiol       Date:  1991-03       Impact factor: 5.948

3.  Characterization of an isogenic set of methicillin-resistant and susceptible mutants of Staphylococcus aureus.

Authors:  B Berger-Bächi; A Strässle; F H Kayser
Journal:  Eur J Clin Microbiol       Date:  1986-12       Impact factor: 3.267

4.  Increase in transduction efficiency of Tn551 mediated by the methicillin resistance marker.

Authors:  B Berger-Bächi
Journal:  J Bacteriol       Date:  1983-04       Impact factor: 3.490

5.  Staphylococcal peptidoglycan interpeptide bridge biosynthesis: a novel antistaphylococcal target?

Authors:  U Kopp; M Roos; J Wecke; H Labischinski
Journal:  Microb Drug Resist       Date:  1996       Impact factor: 3.431

6.  femA, which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains.

Authors:  H Maidhof; B Reinicke; P Blümel; B Berger-Bächi; H Labischinski
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

7.  Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus.

Authors:  A M Strandén; K Ehlert; H Labischinski; B Berger-Bächi
Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490

8.  Cloning and characterization of femA and femB from Staphylococcus epidermidis.

Authors:  W E Alborn; J Hoskins; S Unal; J E Flokowitsch; C A Hayes; J E Dotzlaf; W K Yeh; P L Skatrud
Journal:  Gene       Date:  1996-11-21       Impact factor: 3.688

9.  Specificities of FemA and FemB for different glycine residues: FemB cannot substitute for FemA in staphylococcal peptidoglycan pentaglycine side chain formation.

Authors:  K Ehlert; W Schröder; H Labischinski
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

10.  Distribution of genes encoding erythromycin ribosomal methylases and an erythromycin efflux pump in epidemiologically distinct groups of staphylococci.

Authors:  E A Eady; J I Ross; J L Tipper; C E Walters; J H Cove; W C Noble
Journal:  J Antimicrob Chemother       Date:  1993-02       Impact factor: 5.790
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  18 in total

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Review 2.  FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci.

Authors:  S Rohrer; B Berger-Bächi
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

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Journal:  FEMS Microbiol Rev       Date:  2015-03-21       Impact factor: 16.408

4.  Uniformity of glycyl bridge lengths in the mature cell walls of fem mutants of methicillin-resistant Staphylococcus aureus.

Authors:  Shasad Sharif; Sung Joon Kim; Harald Labischinski; Jiawei Chen; Jacob Schaefer
Journal:  J Bacteriol       Date:  2013-01-18       Impact factor: 3.490

5.  The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation.

Authors:  S Rohrer; K Ehlert; M Tschierske; H Labischinski; B Berger-Bächi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

Review 6.  Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance.

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7.  Discovery of novel S. aureus autolysins and molecular engineering to enhance bacteriolytic activity.

Authors:  Daniel C Osipovitch; Sophie Therrien; Karl E Griswold
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8.  Lysostaphin-resistant variants of Staphylococcus aureus demonstrate reduced fitness in vitro and in vivo.

Authors:  Caroline Kusuma; Anna Jadanova; Tanya Chanturiya; John F Kokai-Kun
Journal:  Antimicrob Agents Chemother       Date:  2006-11-13       Impact factor: 5.191

Review 9.  Small-Molecule Acetylation by GCN5-Related N-Acetyltransferases in Bacteria.

Authors:  Rachel M Burckhardt; Jorge C Escalante-Semerena
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10.  Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM.

Authors:  Jennifer Shepherd; Michael Ibba
Journal:  J Biol Chem       Date:  2013-07-18       Impact factor: 5.157
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