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Literature DB >> 916823

Inhibition by 5-(tetradecyloxy)-2-furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes.

Abstract

Fatty acid and cholesterol synthesis in isolated rat hepatocytes were strongly inhibited by 5-(tetradecyloxy)-2-furoic acid. With either 3H2O or [2(-14)C] acetate as the labeled precursor, the concentrations of inhibitor causing 50% decrease in fatty acid and cholesterol synthesis were, respectively, less than 0.005 mM and 0.020 mM. At 0.1 mM inhibitor, citrate concentration in cells from fed rats was increased by 75%; lactate and pyruvate concentrations were decreased by 30%; ethanol oxidation was decreased by 20%; with cells from starved rats, the mitochondrial [NAD+]/[NADH] was decreased. Other parameters were unaffected. Both its potency and its specificity indicate that 5-(tetradecyloxy)-2-furoic acid will be useful in studies on the regulation of lipid biosynthesis.

Entities: Chemical Species

Mesh：

Substances：

Year: 1977 PMID： 916823 DOI： 10.1007/bf02533270

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

17 in total

1. EFFECTS OF ALPHA-P-CHLOROPHENOXYISOBUTYRYL ETHYL ESTER (CPIB) WITH AND WITHOUT ANDROSTERONE ON CHOLESTEROL BIOSYNTHESIS IN RAT LIVER.

Authors: D R AVOY; E A SWYRYD; R G GOULD
Journal: J Lipid Res Date: 1965-07 Impact factor: 5.922

2. Effect of surface active agents on the latent ATPase of mitochondria.

Authors: H A LARDY; B C PRESSMAN
Journal: Biochim Biophys Acta Date: 1956-09

3. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

Authors: R A Harris
Journal: Arch Biochem Biophys Date: 1975-07 Impact factor: 4.013

4. Subcellular distribution of key metabolites in isolated liver cells from fasted rats.

Authors: E A Siess; D G Brocks; O H Wieland
Journal: FEBS Lett Date: 1976-10-15 Impact factor: 4.124

5. Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP: citrate oxaloacetate lyase.

Authors: J A Watson; M Fang; J M Lowenstein
Journal: Arch Biochem Biophys Date: 1969-12 Impact factor: 4.013

6. Acceleration of gluconeogenesis from lactate by lysine (Short Communication).

Authors: N W Cornell; P Lund; R Hems; H A Krebs
Journal: Biochem J Date: 1973-06 Impact factor: 3.857

7. The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver.

Authors: R L Veech; R Guynn; D Veloso
Journal: Biochem J Date: 1972-04 Impact factor: 3.857

8. The effect of lysine on gluconeogenesis from lactate in rat hepatocytes.

Authors: N W Cornell; P Lund; H A Krebs
Journal: Biochem J Date: 1974-08 Impact factor: 3.857

9. The specificities and configurations of ternary complexes of yeast and liver alcohol dehydrogenases.

Authors: F M Dickinson; K Dalziel
Journal: Biochem J Date: 1967-07 Impact factor: 3.857

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors: M N Berry; D S Friend
Journal: J Cell Biol Date: 1969-12 Impact factor: 10.539

10 in total

1. Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process.

Authors: B Crabtree; M J Souter; S E Anderson
Journal: Biochem J Date: 1989-02-01 Impact factor: 3.857

2. Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.

Authors: M Benito; D H Williamson
Journal: Biochem J Date: 1978-10-15 Impact factor: 3.857

3. Fatty acid metabolism in hepatocytes isolated from rats adapted to high-fat diets containing long- or medium-chain triacylglycerols.

Authors: J P Pégorier; P H Duée; C Herbin; P Y Laulan; C Bladé; J Peret; J Girard
Journal: Biochem J Date: 1988-02-01 Impact factor: 3.857

Inhibition by 5-(tetradecyloxy)-2-furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes.

1. EFFECTS OF ALPHA-P-CHLOROPHENOXYISOBUTYRYL ETHYL ESTER (CPIB) WITH AND WITHOUT ANDROSTERONE ON CHOLESTEROL BIOSYNTHESIS IN RAT LIVER.

2. Effect of surface active agents on the latent ATPase of mitochondria.

3. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

4. Subcellular distribution of key metabolites in isolated liver cells from fasted rats.

5. Tricarballylate and hydroxycitrate: substrate and inhibitor of ATP: citrate oxaloacetate lyase.

6. Acceleration of gluconeogenesis from lactate by lysine (Short Communication).

7. The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver.

8. The effect of lysine on gluconeogenesis from lactate in rat hepatocytes.

9. The specificities and configurations of ternary complexes of yeast and liver alcohol dehydrogenases.

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

1. Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process.

2. Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating rats.

3. Fatty acid metabolism in hepatocytes isolated from rats adapted to high-fat diets containing long- or medium-chain triacylglycerols.

4. Regulation of ketogenesis during the suckling-weanling transition in the rat. Studies with isolated hepatocytes.

5. Fatty acids are required for epidermal permeability barrier function.

6. Development and regulation of ketogenesis in hepatocytes isolated from newborn rats.

7. Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid.

8. Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid.

9. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7.

10. Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts.