Literature DB >> 4342558

The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver.

R L Veech, R Guynn, D Veloso.   

Abstract

1. The time-course of the effects of ethanol administration on the metabolite concentrations, redox states and phosphorylation state was studied in the freeze-clamped liver of starved rats. The response was found to vary with the time after ethanol administration. 2. Administration of ethanol caused an immediate decrease in the [NAD(+)]/[NADH] ratio of both cytoplasm and mitochondria, which persisted over the 30min studied. 3. The free cytoplasmic [NADP(+)]/[NADPH] ratio in liver decreases immediately after ethanol administration but returns nearly to control values after 15min. 4. The cytoplasmic [ATP]/[ADP][HPO(4) (2-)] ratio is elevated 15min after ethanol administration in the starved rat. 5. The rapid and large changes in most metabolite concentrations measured appeared to result from the maintenance of near-equilibrium in a wide interlinked network. 6. Differences between fed and starved rats 15min after ethanol administration were slight.

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Year:  1972        PMID： 4342558      PMCID： PMC1178599          DOI： 10.1042/bj1270387

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

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Authors:  D H Williamson; P Lund; H A Krebs
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Authors:  R L Veech; L Raijman; H A Krebs
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Journal:  Biochem J       Date:  1966-09       Impact factor: 3.857
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  41 in total

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9.  Contribution of NADH increases to ethanol's inhibition of retinol oxidation by human ADH isoforms.

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10.  Lactate-stimulated ethanol oxidation in isolated rat hepatocytes.

Authors:  K E Crow; N W Cornell; R L Veech
Journal:  Biochem J       Date:  1978-04-15       Impact factor: 3.857
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