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Literature DB >> 502765

Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid.

Abstract

2-Tetradecylglycidic acid (TDGA), a hypoglycemic agent, has been found to be a very effective inhibitor of de novo fatty acid synthesis by isolated hepatocytes. A comparison was made between the effectiveness of TDGA and 5-(tetradecyloxy)-2-furoic acid (TOFA), a hypolipidemic agent, on the metabolic processes of isolated hepatocytes. These compounds are structurally related and both inhibit fatty acid synthesis; however, they have opposite effects from each other on the oxidation and esterification of fatty acids. TDGA inhibits whereas TOFA stimulates fatty acid oxidation. TDGA stimulates whereas TOFA inhibits fatty acid esterification.

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 502765 DOI： 10.1007/bf02534133

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

11 in total

1. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

Authors: D H WILLIAMSON; J MELLANBY; H A KREBS
Journal: Biochem J Date: 1962-01 Impact factor: 3.857

2. [On the metabolite content and the metabolite concentration in the liver of the rat].

Authors: H J HOHORST; F H KREUTZ; T BUECHER
Journal: Biochem Z Date: 1959

3. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

Authors: R A Harris
Journal: Arch Biochem Biophys Date: 1975-07 Impact factor: 4.013

4. Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed rats.

Authors: R Z Christiansen
Journal: Biochim Biophys Acta Date: 1977-08-24

5. Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively.

Authors: G F Tutwiler; R Mohrbacher; W Ho
Journal: Diabetes Date: 1979-03 Impact factor: 9.461

3. Inhibitors of Fatty Acid Synthesis Induce PPAR α -Regulated Fatty Acid β -Oxidative Genes: Synergistic Roles of L-FABP and Glucose.

Authors: Huan Huang; Avery L McIntosh; Gregory G Martin; Anca D Petrescu; Kerstin K Landrock; Danilo Landrock; Ann B Kier; Friedhelm Schroeder
Journal: PPAR Res Date: 2013-02-26 Impact factor: 4.964

3 in total

Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid.

1. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

2. [On the metabolite content and the metabolite concentration in the liver of the rat].

3. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate.

4. Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed rats.

5. Methyl 2-tetradecylglycidate, an orally effective hypoglycemic agent that inhibits long chain fatty acid oxidation selectively.

6. Inhibition of fatty acid synthesis by RMI 14,514 (5-tetradecyloxy-2-furoic acid).

7. Inhibition by 5-(tetradecyloxy)-2-furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytes.

8. Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)--an orally effective hypoglycemic agent.

9. Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes.

10. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

1. Effects of phorbol esters, A23187 and vasopressin on oleate metabolism in isolated rat hepatocytes.

2. Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase.

3. Inhibitors of Fatty Acid Synthesis Induce PPAR α -Regulated Fatty Acid β -Oxidative Genes: Synergistic Roles of L-FABP and Glucose.