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Literature DB >> 909787

Polynucleotides. XLV Synthesis and properties of poly(2'-azido-2'-deoxyinosinic acid).

Abstract

Poly (2'-azido-2'-deoxyinosinic acid), [poly (Iz)], was synthesized from 2'-azido-2'-deoxyinosine diphosphate by the action of polynucleotide phosphorylase. Poly (Iz) has UV absorption properties similar to poly (I) and hypochromicity of 11% at 0.15M Na+ and neutrality. In solutions of high Na+ ion concentration, poly (Iz) forms a multi-stranded complex and its Tm at 1.0M Na+ ion concentration was 43 degrees. Upon mixing with poly (C), poly (Iz) forms a 1:1 complex having a Tm lower than that of poly (I)-poly (C) complex in the same conditions. The effect of substitution at the 2'-position of the poly (I) strand was discussed in relation to the interferon-inducing activity.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1977 PMID： 909787 PMCID： PMC342597 DOI： 10.1093/nar/4.8.2629

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

16 in total

1. PHYSICAL AND CHEMICAL CHARACTERIZATION OF THE ORDERED COMPLEXES FORMED BETWEEN POLYINOSINIC ACID, POLYCYTIDYLIC ACID AND THEIR DEOXYRIBO-ANALOGUES.

Authors: M J CHAMBERLIN; D L PATTERSON
Journal: J Mol Biol Date: 1965-06 Impact factor: 5.469

2. The molecular structure of polyinosinic acid.

Authors: A RICH
Journal: Biochim Biophys Acta Date: 1958-09

3. The estimation of phosphorus.

Authors: R J Allen
Journal: Biochem J Date: 1940-06 Impact factor: 3.857

4. Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid.

Authors: M Ikehara; T Fukui; N Kakiuchi
Journal: Nucleic Acids Res Date: 1976-08 Impact factor: 16.971

5. Polynucleotides containing 2'-chloro-2'-deoxyribose.

Authors: J Hobbs; H Sternbach; M Sprinzl; F Eckstein
Journal: Biochemistry Date: 1972-11-07 Impact factor: 3.162

6. A novel procedure for the synthesis of 2'-O-alkyl nucleotides.

Authors: I Tazawa; S Tazawa; J L Alderfer; P O Ts'o
Journal: Biochemistry Date: 1972-12-19 Impact factor: 3.162

7. Synthesis and properties of poly 2'-fluoro-2'-deoxyuridylic acid.

Authors: B Janik; M P Kotick; T H Kreiser; L F Reverman; R G Sommer; D P Wilson
Journal: Biochem Biophys Res Commun Date: 1972-02-16 Impact factor: 3.575

8. Synthesis and characterization of potential interferon inducers. Poly(2'-azido-2'-deoxyuridylic acid).

Authors: P F Torrence; A M Bobst; J A Waters; B Witkop
Journal: Biochemistry Date: 1973-09-25 Impact factor: 3.162

9. Structures for polyinosinic acid and polyguanylic acid.

Authors: S Arnott; R Chandrasekaran; C M Marttila
Journal: Biochem J Date: 1974-08 Impact factor: 3.857

10. Polynucleotides containing 2'-amino-2'-deoxyribose and 2'-azido-2'-deoxyribose.

Authors: J Hobbs; H Sternbach; M Sprinzl; F Eckstein
Journal: Biochemistry Date: 1973-12-04 Impact factor: 3.162

5 in total

1. Polynucleotides. LII. Synthesis and properties of poly(2'-deoxy-2'-fluoroadenylic acid).

Authors: M Ikehara; T Fukui; N Kakiuchi
Journal: Nucleic Acids Res Date: 1978-06 Impact factor: 16.971

2. Specific interaction of netropsin, distamycin-3 and analogs with LC duplexes: reversion towards the B form of the 2'-deoxy-.2'-deoxy-2'-fluoro-hybrid duplexes upon specific interaction with netropsin, distamycin-3 and analogs.

Authors: C Marck; N Kakiuchi; W Guschlbauer
Journal: Nucleic Acids Res Date: 1982-10-11 Impact factor: 16.971

3. Polynucleotides. L. Synthesis and properties of poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo-2'-deoxyadenylic acid).

Authors: M Ikehara; T Fukui; N Kakiuchi
Journal: Nucleic Acids Res Date: 1977-12 Impact factor: 16.971

4. Polynucleotides. LVI. Synthesis and properties of poly(2-deoxy-2'-fluoroinosinic acid).

Authors: M Ikehara; N Kakiuchi; T Fukui
Journal: Nucleic Acids Res Date: 1978-09 Impact factor: 16.971

5. Polynucleotides. LVII. Synthesis and properties of poly (2'-chloro-2'-deoxyinosinic acid).

Authors: N Kakiuchi; T Fukui; M Ikehara
Journal: Nucleic Acids Res Date: 1979-06-11 Impact factor: 16.971

5 in total