Literature DB >> 9066302

Benzophenone photoprobes for phosphoinositides, peptides and drugs.

G D Prestwich1, G Dormán, J T Elliott, D M Marecak, A Chaudhary.   

Abstract

Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high-efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligo) nucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used in biochemistry.

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Year:  1997        PMID： 9066302     DOI： 10.1111/j.1751-1097.1997.tb08548.x

Source DB:  PubMed          Journal:  Photochem Photobiol        ISSN： 0031-8655            Impact factor:   3.421


  20 in total

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