| Literature DB >> 26420066 |
Doina M Mihai1, Steven Hall1, Haiteng Deng2, Christopher J Welch3, Akira Kawamura1.
Abstract
Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.Entities:
Keywords: Doxorubicin; Fenofibrate; GLO1; Ketoprofen; Off-target; Photoaffinity-labeling
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Year: 2015 PMID： 26420066 PMCID： PMC4628877 DOI： 10.1016/j.bmcl.2015.09.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823