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Literature DB >> 20383152

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

Kalinka Koteva¹, Hee-Jeon Hong, Xiao Dong Wang, Ishac Nazi, Donald Hughes, Mike J Naldrett, Mark J Buttner, Gerard D Wright.

Abstract

Inducible resistance to the glycopeptide antibiotic vancomycin requires expression of vanH, vanA and vanX, controlled by a two-component regulatory system consisting of a receptor histidine kinase, VanS, and a response regulator, VanR. The identity of the VanS receptor ligand has been debated. Using a synthesized vancomycin photoaffinity probe, we show that vancomycin directly binds Streptomyces coelicolor VanS (VanSsc) and this binding is correlated with resistance and required for vanH, vanA and vanX gene expression.

Entities: Chemical Species

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Year: 2010 PMID： 20383152 DOI： 10.1038/nchembio.350

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

23 in total

1. Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors.

Authors: J M Neu; G D Wright
Journal: FEMS Microbiol Lett Date: 2001-05-15 Impact factor: 2.742

Review 2. Glycopeptide and lipoglycopeptide antibiotics.

Authors: Dan Kahne; Catherine Leimkuhler; Wei Lu; Christopher Walsh
Journal: Chem Rev Date: 2005-02 Impact factor: 60.622

3. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.

Authors: C G Marshall; G Broadhead; B K Leskiw; G D Wright
Journal: Proc Natl Acad Sci U S A Date: 1997-06-10 Impact factor: 11.205

4. Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis.

Authors: M Baptista; F Depardieu; P Courvalin; M Arthur
Journal: Antimicrob Agents Chemother Date: 1996-10 Impact factor: 5.191

5. A vancomycin-inducible lacZ reporter system in Bacillus subtilis: induction by antibiotics that inhibit cell wall synthesis and by lysozyme.

Authors: A T Ulijasz; A Grenader; B Weisblum
Journal: J Bacteriol Date: 1996-11 Impact factor: 3.490

6. Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis.

Authors: R Sinha Roy; P Yang; S Kodali; Y Xiong; R M Kim; P R Griffin; H R Onishi; J Kohler; L L Silver; K Chapman
Journal: Chem Biol Date: 2001-11

7. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

Authors: M Arthur; C Molinas; P Courvalin
Journal: J Bacteriol Date: 1992-04 Impact factor: 3.490

8. The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor.

Authors: Matthew I Hutchings; Hee-Jeon Hong; Mark J Buttner
Journal: Mol Microbiol Date: 2006-02 Impact factor: 3.501

9. Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics.

Authors: N E Allen; J N Hobbs
Journal: FEMS Microbiol Lett Date: 1995-10-01 Impact factor: 2.742

10. Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.

Authors: Hee-Jeon Hong; Matthew I Hutchings; John M Neu; Gerard D Wright; Mark S B Paget; Mark J Buttner
Journal: Mol Microbiol Date: 2004-05 Impact factor: 3.501

55 in total

9. Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.

Authors: Joseph R Pinchman; Dale L Boger
Journal: J Med Chem Date: 2013-05-13 Impact factor: 7.446

10. Artificial opsonin enhances bacterial phagocytosis, oxidative burst and chemokine production by human neutrophils.

Authors: Kristy N Katzenmeyer; Luisa M Szott; James D Bryers
Journal: Pathog Dis Date: 2017-08-31 Impact factor: 3.166

A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor.

1. Inhibition of sporulation, glycopeptide antibiotic production and resistance in Streptomyces toyocaensis NRRL 15009 by protein kinase inhibitors.

Review 2. Glycopeptide and lipoglycopeptide antibiotics.

3. D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.

4. Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis.

5. A vancomycin-inducible lacZ reporter system in Bacillus subtilis: induction by antibiotics that inhibit cell wall synthesis and by lysozyme.

6. Direct interaction of a vancomycin derivative with bacterial enzymes involved in cell wall biosynthesis.

7. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

8. The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor.

9. Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics.

10. Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.

Review 1. Messenger functions of the bacterial cell wall-derived muropeptides.

2. Signal perception by the secretion stress-responsive CssRS two-component system in Bacillus subtilis.

3. Antibiotics: vancomycin sensing.

4. Identifying producers of antibacterial compounds by screening for antibiotic resistance.

Review 5. Antibiotics as probes of biological complexity.

6. Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.

7. Glycopeptide sulfation evades resistance.

8. Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance.

9. Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.

10. Artificial opsonin enhances bacterial phagocytosis, oxidative burst and chemokine production by human neutrophils.