Literature DB >> 8849219

Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.

T Deguchi1, M Yasuda, M Nakano, S Ozeki, T Ezaki, I Saito, Y Kawada.   

Abstract

Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.

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Year:  1996        PMID： 8849219      PMCID： PMC163251     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Authors:  H Yoshida; M Bogaki; M Nakamura; S Nakamura
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

2.  Detection of the tetM determinant in Neisseria gonorrhoeae.

Authors:  C A Ison; N Tekki; M J Gill
Journal:  Sex Transm Dis       Date:  1993 Nov-Dec       Impact factor: 2.830

3.  High prevalence of Neisseria gonorrhoeae strains with reduced susceptibility to fluoroquinolones in Japan.

Authors:  M Tanaka; J Kumazawa; T Matsumoto; I Kobayashi
Journal:  Genitourin Med       Date:  1994-04

4.  Characterization of a gyrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeae.

Authors:  D C Stein; R J Danaher; T M Cook
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

5.  Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones.

Authors:  L Ferrero; B Cameron; B Manse; D Lagneaux; J Crouzet; A Famechon; F Blanche
Journal:  Mol Microbiol       Date:  1994-08       Impact factor: 3.501

6.  Susceptibility of Neisseria gonorrhoeae associated with pelvic inflammatory disease to cefoxitin, ceftriaxone, clindamycin, gentamicin, doxycycline, azithromycin, and other antimicrobial agents.

Authors:  R J Rice; J S Knapp
Journal:  Antimicrob Agents Chemother       Date:  1994-07       Impact factor: 5.191

7.  Sentinel surveillance for antimicrobial resistance in Neisseria gonorrhoeae--United States, 1988-1991. The Gonococcal Isolate Surveillance Project Study Group.

Authors:  R J Gorwitz; A K Nakashima; J S Moran; J S Knapp
Journal:  MMWR CDC Surveill Summ       Date:  1993-08-13

8.  DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.

Authors:  T Deguchi; M Yasuda; M Asano; K Tada; H Iwata; H Komeda; T Ezaki; I Saito; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

9.  Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.

Authors:  R J Belland; S G Morrison; C Ison; W M Huang
Journal:  Mol Microbiol       Date:  1994-10       Impact factor: 3.501
  9 in total
  43 in total

1.  Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India.

Authors:  U Chaudhry; K Ray; M Bala; D Saluja
Journal:  Sex Transm Infect       Date:  2002-12       Impact factor: 3.519

2.  Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998.

Authors:  M Tanaka; H Nakayama; M Haraoka; T Saika
Journal:  J Clin Microbiol       Date:  2000-02       Impact factor: 5.948

3.  Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.

Authors:  Julie Giles; Justin Hardick; Jeffrey Yuenger; Michael Dan; Karl Reich; Jonathan Zenilman
Journal:  J Clin Microbiol       Date:  2004-07       Impact factor: 5.948

4.  Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones.

Authors:  Masayasu Ito; Mitsuru Yasuda; Shigeaki Yokoi; Shin-ichi Ito; Yoshito Takahashi; Satoshi Ishihara; Shin-ichi Maeda; Takashi Deguchi
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

5.  Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in Central Japan.

Authors:  Masayasu Ito; Takashi Deguchi; Koh-Suke Mizutani; Mitsuru Yasuda; Shigeaki Yokoi; Shin-Ichi Ito; Yoshito Takahashi; Satoshi Ishihara; Yoshiaki Kawamura; Takayuki Ezaki
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

6.  Moxifloxacin versus ofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease: results of a multicentre, double blind, randomised trial.

Authors:  J D C Ross; H S Cronjé; T Paszkowski; I Rakoczi; D Vildaite; A Kureishi; M Alefelder; P Arvis; P Reimnitz
Journal:  Sex Transm Infect       Date:  2006-05-24       Impact factor: 3.519

7.  Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae.

Authors:  D L Trees; A L Sandul; W L Whittington; J S Knapp
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

Review 8.  Antimicrobial agents and gonorrhoea: therapeutic choice, resistance and susceptibility testing.

Authors:  C A Ison
Journal:  Genitourin Med       Date:  1996-08

9.  Draft Genome Sequence of Neisseria gonorrhoeae Strain NG_869 with Penicillin, Tetracycline and Ciprofloxacin Resistance Determinants Isolated from Malaysia.

Authors:  Geik Yong Ang; Choo Yee Yu; Delicia Ann Yong; Yuet Meng Cheong; Wai-Fong Yin; Kok-Gan Chan
Journal:  Indian J Microbiol       Date:  2016-02-08       Impact factor: 2.461

10.  Drift in susceptibility of Neisseria gonorrhoeae to ciprofloxacin and emergence of therapeutic failure.

Authors:  C A Ison; P J Woodford; H Madders; E Claydon
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191
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