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Literature DB >> 12121955

Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.

Somesh Baranwal¹, Keya Dey, T Ramamurthy, G Balakrish Nair, Manikuntala Kundu.

Abstract

Quinolones are among the drugs of choice in the management of cholera caused by Vibrio cholerae. In this study, we demonstrate that, in addition to mutations detected in the target genes gyrA and parC, proton motive force-dependent efflux is involved in quinolone resistance in clinical isolates of V. cholerae.

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Year: 2002 PMID： 12121955 PMCID： PMC127385 DOI： 10.1128/AAC.46.8.2676-2678.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

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Journal: Antimicrob Agents Chemother Date: 1990-05 Impact factor: 5.191

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Journal: Mol Microbiol Date: 1998-01 Impact factor: 3.501

6. Efficacy of norfloxacin and doxycycline for treatment of vibrio cholerae 0139 infection.

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Journal: J Antimicrob Chemother Date: 1996-03 Impact factor: 5.790

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Journal: Antimicrob Agents Chemother Date: 1997-03 Impact factor: 5.191

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Authors: P Garg; S Chakraborty; I Basu; S Datta; K Rajendran; T Bhattacharya; S Yamasaki; S K Bhattacharya; Y Takeda; G B Nair; T Ramamurthy
Journal: Epidemiol Infect Date: 2000-06 Impact factor: 2.451

9. Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.

Authors: M Oethinger; W V Kern; A S Jellen-Ritter; L M McMurry; S B Levy
Journal: Antimicrob Agents Chemother Date: 2000-01 Impact factor: 5.191

Review 10. Clinical applications of quinolones.

Authors: D C Hooper
Journal: Biochim Biophys Acta Date: 1998-10-01

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3. Difference of Phenotype and Genotype Between Human and Environmental: Isolated Vibrio cholerae in Surabaya, Indonesia.

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4. Genomic diversity of 2010 Haitian cholera outbreak strains.

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Journal: Proc Natl Acad Sci U S A Date: 2012-06-18 Impact factor: 11.205

5. Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance.

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6. Reduced expression of the vca0421 gene of Vibrio cholerae O1 results in innate resistance to ciprofloxacin.

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Journal: Antimicrob Agents Chemother Date: 2010-08-30 Impact factor: 5.191

7. Transferable quinolone resistance in Vibrio cholerae.

Authors: Hong Bin Kim; Minghua Wang; Sabeena Ahmed; Chi Hye Park; Regina C LaRocque; Abu S G Faruque; Mohammed A Salam; Wasif A Khan; Firdausi Qadri; Stephen B Calderwood; George A Jacoby; David C Hooper
Journal: Antimicrob Agents Chemother Date: 2009-11-30 Impact factor: 5.191