| Literature DB >> 8990161 |
L Gold1, D Brown, Y He, T Shtatland, B S Singer, Y Wu.
Abstract
The SELEX method and oligonucleotide combinatorial chemistry discovery process yields high-affinity/high-specificity ligands for virtually any molecular target. Typically, the enormous starting libraries used in the SELEX process contain 10(14)-10(15) sequences. We now ask if the smaller sequences, complexity of extant organisms, and evolutionary history provide useful interactions between oligonucleotides and at least some unexpected targets. That is, do organisms contain a robust "linkage map" between their oligonucleotides and proteins and/or small molecules that enriches life?Entities:
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Year: 1997 PMID： 8990161 PMCID： PMC19236 DOI： 10.1073/pnas.94.1.59
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205