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Literature DB >> 7029523

Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function.

Abstract

The bacteriophage T4 gene regA encodes a protein that diminishes the expression of many unlinked early T4 genes. Previous work demonstrated that regA-mediated repression occurs after transcription. We report here on the identification of the target site on one regA-sensitive mRNA, the message encoding the phage T4 rIIB protein. The target for regA-mediated action overlaps the translational initiation domain of the rIIB messenger. The regA protein may be a repressor that operates translationally on a significant and interesting set of early phage T4 mRNAs.

Entities: Gene Species

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Year: 1981 PMID： 7029523 PMCID： PMC320220 DOI： 10.1073/pnas.78.8.4669

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

50 in total

1. Early enzyme synthesis and its control in E. coli infected with some amber mutants of bacteriophage T4.

Authors: J S WIBERG; M L DIRKSEN; R H EPSTEIN; S E LURIA; J M BUCHANAN
Journal: Proc Natl Acad Sci U S A Date: 1962-02 Impact factor: 11.205

2. ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.

Authors: S Benzer
Journal: Proc Natl Acad Sci U S A Date: 1961-03 Impact factor: 11.205

3. The regulatory region of MS2 phage RNA replicase cistron. IV. Functional activity of specific MS2 RNA fragments in formation of the 70 S initiation complex of protein biosynthesis.

Authors: G P Borisova; T M Volkova; V Berzin; G Rosenthal; E J Gren
Journal: Nucleic Acids Res Date: 1979 Impact factor: 16.971

Review 9. Bacteriophage T4 genome.

Authors: Eric S Miller; Elizabeth Kutter; Gisela Mosig; Fumio Arisaka; Takashi Kunisawa; Wolfgang Rüger
Journal: Microbiol Mol Biol Rev Date: 2003-03 Impact factor: 11.056

10. The bacteriophage T4 dexA gene: sequence and analysis of a gene conditionally required for DNA replication.

Authors: P Gauss; M Gayle; R B Winter; L Gold
Journal: Mol Gen Genet Date: 1987-01

Translational regulation: identification of the site on bacteriophage T4 rIIB mRNA recognized by the regA gene function.

1. Early enzyme synthesis and its control in E. coli infected with some amber mutants of bacteriophage T4.

2. ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.

3. The regulatory region of MS2 phage RNA replicase cistron. IV. Functional activity of specific MS2 RNA fragments in formation of the 70 S initiation complex of protein biosynthesis.

4. Purification of the gene 43, 44, 45, and 62 proteins of the bacteriophage T4 DNA replication apparatus.

5. Control of gene function in bacteriophage T4. IV. Post-transcriptional shutoff of expression of early genes.

6. Nucleotide sequence at the binding site for coat protein on RNA of bacteriophage R17.

7. Specific recognition of the isolated R17 replicase initiator region by R17 coat protein.

8. Q replicase as repressor of Q RNA-directed protein synthesis.

9. regA protein of bacteriophage T4D: identification, schedule of synthesis, and autogenous regulation.

10. Bacteriophage T4 RNA ligase is gene 63 product, the protein that promotes tail fiber attachment to the baseplate.

1. Mutational analysis of the mRNA operator for T4 DNA polymerase.

2. Regions of bacteriophage T4 and RB69 RegA translational repressor proteins that determine RNA-binding specificity.

3. Binding of the bacteriophage T4 regA protein to mRNA targets: an initiator AUG is required.

Review 4. Nucleolytic processing of ribonucleic acid transcripts in procaryotes.

5. Sequence analysis of conserved regA and variable orf43.1 genes in T4-like bacteriophages.

6. Gene organization and transcription of a late-expressed region of a Lactococcus lactis phage.

7. Bacteriophage T4 regA protein binds RNA as a monomer, overcoming dimer interactions.

8. Genetic definition of the translational operator of the threonine-tRNA ligase gene in Escherichia coli.

Review 9. Bacteriophage T4 genome.

10. The bacteriophage T4 dexA gene: sequence and analysis of a gene conditionally required for DNA replication.