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Literature DB >> 8962148

Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.

Abstract

Aspergillus nidulans contains two functionally distinct fatty acid synthases (FASs): one required for primary fatty acid metabolism (FAS) and the other required for secondary metabolism (sFAS). FAS mutants require long-chain fatty acids for growth, whereas sFAS mutants grow normally but cannot synthesize sterigmatocystin (ST), a carcinogenic secondary metabolite structurally and biosynthetically related to aflatoxin. sFAS mutants regain the ability to synthesize ST when provided with hexanoic acid, supporting the model that the ST polyketide synthase uses this short-chain fatty acid as a starter unit. The characterization of both the polyketide synthase and FAS may provide novel means for modifying secondary metabolites.

Entities: Chemical Disease Species

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Year: 1996 PMID： 8962148 PMCID： PMC26229 DOI： 10.1073/pnas.93.25.14873

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

30 in total

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Journal: Mol Gen Genet Date: 1976-07-23

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Journal: Gene Date: 1987 Impact factor: 3.688

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Journal: J Biol Chem Date: 1988-09-05 Impact factor: 5.157

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Authors: J H Yu; T J Leonard
Journal: J Bacteriol Date: 1995-08 Impact factor: 3.490

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Journal: Mol Gen Genet Date: 1986-06

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Journal: Proc Natl Acad Sci U S A Date: 1994-11-22 Impact factor: 11.205

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Authors: T H Adams; M T Boylan; W E Timberlake
Journal: Cell Date: 1988-07-29 Impact factor: 41.582

9. Analysis and expression of the Candida albicans FAS2 gene.

Authors: S B Southard; R L Cihlar
Journal: Gene Date: 1995-04-14 Impact factor: 3.688

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Journal: Mol Cell Biol Date: 1985-07 Impact factor: 4.272

42 in total

Review 1. Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.

Authors: Eckhart Schweizer; Jörg Hofmann
Journal: Microbiol Mol Biol Rev Date: 2004-09 Impact factor: 11.056

Review 2. Clustered pathway genes in aflatoxin biosynthesis.

Authors: Jiujiang Yu; Perng-Kuang Chang; Kenneth C Ehrlich; Jeffrey W Cary; Deepak Bhatnagar; Thomas E Cleveland; Gary A Payne; John E Linz; Charles P Woloshuk; Joan W Bennett
Journal: Appl Environ Microbiol Date: 2004-03 Impact factor: 4.792

Review 3. New insights into the formation of fungal aromatic polyketides.

Authors: Jason M Crawford; Craig A Townsend
Journal: Nat Rev Microbiol Date: 2010-12 Impact factor: 60.633

4. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans.

Authors: Dimitrios I Tsitsigiannis; Terri M Kowieski; Robert Zarnowski; Nancy P Keller
Journal: Eukaryot Cell Date: 2004-12

5. Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".

Authors: Jason M Crawford; Anna L Vagstad; Karen P Whitworth; Kenneth C Ehrlich; Craig A Townsend
Journal: Chembiochem Date: 2008-05-05 Impact factor: 3.164

6. Genome Characterization of Oleaginous Aspergillus oryzae BCC7051: A Potential Fungal-Based Platform for Lipid Production.

Authors: Chinae Thammarongtham; Intawat Nookaew; Tayvich Vorapreeda; Tanawut Srisuk; Miriam L Land; Sukanya Jeennor; Kobkul Laoteng
Journal: Curr Microbiol Date: 2017-09-01 Impact factor: 2.188

7. Are Pfiesteria species toxicogenic? Evidence against production of ichthyotoxins by Pfiesteria shumwayae.

Authors: J P Berry; K S Reece; K S Rein; D G Baden; L W Haas; W L Ribeiro; J D Shields; R V Snyder; W K Vogelbein; R E Gawley
Journal: Proc Natl Acad Sci U S A Date: 2002-08-05 Impact factor: 11.205

8. Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase.

Authors: Jason M Crawford; Blair C R Dancy; Eric A Hill; Daniel W Udwary; Craig A Townsend
Journal: Proc Natl Acad Sci U S A Date: 2006-10-27 Impact factor: 11.205

9. Terbinafine resistance mediated by salicylate 1-monooxygenase in Aspergillus nidulans.

Authors: Marcia A S Graminha; Eleusa M F Rocha; Rolf A Prade; Nilce M Martinez-Rossi
Journal: Antimicrob Agents Chemother Date: 2004-09 Impact factor: 5.191

10. Chromatin-level regulation of biosynthetic gene clusters.

Authors: Jin Woo Bok; Yi-Ming Chiang; Edyta Szewczyk; Yazmid Reyes-Dominguez; Ashley D Davidson; James F Sanchez; Hsien-Chun Lo; Kenji Watanabe; Joseph Strauss; Berl R Oakley; Clay C C Wang; Nancy P Keller
Journal: Nat Chem Biol Date: 2009-07 Impact factor: 15.040