Literature DB >> 19448638

Chromatin-level regulation of biosynthetic gene clusters.

Jin Woo Bok1, Yi-Ming Chiang, Edyta Szewczyk, Yazmid Reyes-Dominguez, Ashley D Davidson, James F Sanchez, Hsien-Chun Lo, Kenji Watanabe, Joseph Strauss, Berl R Oakley, Clay C C Wang, Nancy P Keller.   

Abstract

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.

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Year:  2009        PMID： 19448638      PMCID： PMC2891026          DOI： 10.1038/nchembio.177

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  23 in total

1.  LaeA, a regulator of secondary metabolism in Aspergillus spp.

Authors:  Jin Woo Bok; Nancy P Keller
Journal:  Eukaryot Cell       Date:  2004-04

2.  VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism.

Authors:  Ozgür Bayram; Sven Krappmann; Min Ni; Jin Woo Bok; Kerstin Helmstaedt; Oliver Valerius; Susanna Braus-Stromeyer; Nak-Jung Kwon; Nancy P Keller; Jae-Hyuk Yu; Gerhard H Braus
Journal:  Science       Date:  2008-06-13       Impact factor: 47.728

Review 3.  Telomeric position effect: from the yeast paradigm to human pathologies?

Authors:  Alexandre Ottaviani; Eric Gilson; Frédérique Magdinier
Journal:  Biochimie       Date:  2007-08-06       Impact factor: 4.079

4.  Aspergillus has distinct fatty acid synthases for primary and secondary metabolism.

Authors:  D W Brown; T H Adams; N P Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

5.  The initiation and pattern of spread of histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin cluster.

Authors:  Ludmila V Roze; Anna E Arthur; Sung-Yong Hong; Anindya Chanda; John E Linz
Journal:  Mol Microbiol       Date:  2007-10-05       Impact factor: 3.501

6.  Rational elimination of Aspergillus terreus sulochrin production.

Authors:  Robin D Couch; G Maurice Gaucher
Journal:  J Biotechnol       Date:  2004-03-04       Impact factor: 3.307

7.  Secondary chemicals protect mould from fungivory.

Authors:  Marko Rohlfs; Martin Albert; Nancy P Keller; Frank Kempken
Journal:  Biol Lett       Date:  2007-10-22       Impact factor: 3.703

8.  Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium.

Authors:  Yanxia Wu; Xin Tu; Guosheng Lin; Hao Xia; Hao Huang; Jing Wan; Zhide Cheng; Mengyuan Liu; Gao Chen; Haimou Zhang; Jinrong Fu; Qian Liu; Dong-Xu Liu
Journal:  Life Sci       Date:  2007-09-19       Impact factor: 5.037

9.  Histone deacetylase activity regulates chemical diversity in Aspergillus.

Authors:  E Keats Shwab; Jin Woo Bok; Martin Tribus; Johannes Galehr; Stefan Graessle; Nancy P Keller
Journal:  Eukaryot Cell       Date:  2007-07-06

10.  The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.

Authors:  Christina A Cuomo; Ulrich Güldener; Jin-Rong Xu; Frances Trail; B Gillian Turgeon; Antonio Di Pietro; Jonathan D Walton; Li-Jun Ma; Scott E Baker; Martijn Rep; Gerhard Adam; John Antoniw; Thomas Baldwin; Sarah Calvo; Yueh-Long Chang; David Decaprio; Liane R Gale; Sante Gnerre; Rubella S Goswami; Kim Hammond-Kosack; Linda J Harris; Karen Hilburn; John C Kennell; Scott Kroken; Jon K Magnuson; Gertrud Mannhaupt; Evan Mauceli; Hans-Werner Mewes; Rudolf Mitterbauer; Gary Muehlbauer; Martin Münsterkötter; David Nelson; Kerry O'donnell; Thérèse Ouellet; Weihong Qi; Hadi Quesneville; M Isabel G Roncero; Kye-Yong Seong; Igor V Tetko; Martin Urban; Cees Waalwijk; Todd J Ward; Jiqiang Yao; Bruce W Birren; H Corby Kistler
Journal:  Science       Date:  2007-09-07       Impact factor: 47.728
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  148 in total

1.  Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.

Authors:  Ludmila V Roze; Anindya Chanda; Maris Laivenieks; Randolph M Beaudry; Katherine A Artymovich; Anna V Koptina; Deena W Awad; Dina Valeeva; Arthur D Jones; John E Linz
Journal:  BMC Biochem       Date:  2010-08-24       Impact factor: 4.059

2.  A decade of chemical biology.

Authors:  Mirella Bucci; Catherine Goodman; Terry L Sheppard
Journal:  Nat Chem Biol       Date:  2010-12       Impact factor: 15.040

3.  Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster.

Authors:  Sebastian Bergmann; Alexander N Funk; Kirstin Scherlach; Volker Schroeckh; Ekaterina Shelest; Uwe Horn; Christian Hertweck; Axel A Brakhage
Journal:  Appl Environ Microbiol       Date:  2010-10-15       Impact factor: 4.792

4.  Gene clusters for secondary metabolic pathways: an emerging theme in plant biology.

Authors:  Anne Osbourn
Journal:  Plant Physiol       Date:  2010-10       Impact factor: 8.340

5.  Substrate-induced transcriptional activation of the MoCel7C cellulase gene is associated with methylation of histone H3 at lysine 4 in the rice blast fungus Magnaporthe oryzae.

Authors:  Ba Van Vu; Kieu Thi Minh Pham; Hitoshi Nakayashiki
Journal:  Appl Environ Microbiol       Date:  2013-08-30       Impact factor: 4.792

6.  An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR.

Authors:  Wen-Bing Yin; Saori Amaike; Dana J Wohlbach; Audrey P Gasch; Yi-Ming Chiang; Clay C C Wang; Jin Woo Bok; Marko Rohlfs; Nancy P Keller
Journal:  Mol Microbiol       Date:  2012-02-10       Impact factor: 3.501

7.  Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.

Authors:  James F Sanchez; Yi-Ming Chiang; Edyta Szewczyk; Ashley D Davidson; Manmeet Ahuja; C Elizabeth Oakley; Jin Woo Bok; Nancy Keller; Berl R Oakley; Clay C C Wang
Journal:  Mol Biosyst       Date:  2009-12-16

8.  Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.

Authors:  L Studt; F J Schmidt; L Jahn; C M K Sieber; L R Connolly; E-M Niehaus; M Freitag; H-U Humpf; B Tudzynski
Journal:  Appl Environ Microbiol       Date:  2013-10-04       Impact factor: 4.792

Review 9.  Unlocking fungal cryptic natural products.

Authors:  Yi-Ming Chiang; Kuan-Han Lee; James F Sanchez; Nancy P Keller; Clay C C Wang
Journal:  Nat Prod Commun       Date:  2009-11       Impact factor: 0.986

10.  Accurate prediction of secondary metabolite gene clusters in filamentous fungi.

Authors:  Mikael R Andersen; Jakob B Nielsen; Andreas Klitgaard; Lene M Petersen; Mia Zachariasen; Tilde J Hansen; Lene H Blicher; Charlotte H Gotfredsen; Thomas O Larsen; Kristian F Nielsen; Uffe H Mortensen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-17       Impact factor: 11.205
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