Literature DB >> 894733

Simulation results with stepwise mutation model and their interpretations.

R Chakraborty.   

Abstract

Monte Carlo simulations are performed to compare the predictions based on the two presently used theoretical models for studying genetic variations in natural populations, the infinite allele model and the stepwise mutation model. Distribution of heterozygosity is noticed to be similar under these models until the product of population size and mutation rate is large. It is seen that electromorphs with high population frequency usually contain older allels (at the codon level) than an electromorph of low population frequency. The interpretations of these results in explaining the allelic variations at electrophoretic level is also discussed.

Mesh:

Year:  1977        PMID: 894733     DOI: 10.1007/bf01796093

Source DB:  PubMed          Journal:  J Mol Evol        ISSN: 0022-2844            Impact factor:   2.395


  25 in total

1.  Profiles of electrophoretic alleles in natural populations.

Authors:  A H Brown; D R Marshall; L Albrecht
Journal:  Genet Res       Date:  1975-04       Impact factor: 1.588

2.  Extensions to the model of an infinite number of selectively neutral alleles in a finite population.

Authors:  P J Avery
Journal:  Genet Res       Date:  1975-04       Impact factor: 1.588

3.  THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION.

Authors:  M KIMURA; J F CROW
Journal:  Genetics       Date:  1964-04       Impact factor: 4.562

4.  Electrophoretically silent alleles in a finite population.

Authors:  M Nei; R Chakraborty
Journal:  J Mol Evol       Date:  1976-12-30       Impact factor: 2.395

5.  The transient distribution of allele frequencies under mutation pressure.

Authors:  M Nei; W H Li
Journal:  Genet Res       Date:  1976-12       Impact factor: 1.588

6.  Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.

Authors:  M Kimura; T Ohta
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

7.  Evidence that enzyme polymorphisms are selectively neutral.

Authors:  T Yamazaki; T Maruyama
Journal:  Nat New Biol       Date:  1973-10-03

8.  Simulation studies on electrophoretically detectable genetic variability in a finite population.

Authors:  T Ohta; M Kimura
Journal:  Genetics       Date:  1974-03       Impact factor: 4.562

9.  Genetic distance and electrophoretic identity of proteins between taxa.

Authors:  M Nei; R Chakraborty
Journal:  J Mol Evol       Date:  1973-11-27       Impact factor: 2.395

10.  Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles.

Authors:  M Kimura
Journal:  Genet Res       Date:  1968-06       Impact factor: 1.588

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  4 in total

1.  Short alleles revealed by PCR demonstrate no heterozygote deficiency at minisatellite loci D1S7, D7S21, and D12S11.

Authors:  S Alonso; A Castro; I Fernández-Fernández; M M de Pancorbo
Journal:  Am J Hum Genet       Date:  1997-02       Impact factor: 11.025

2.  Population study of 3 STR loci in the Basque Country (northern Spain).

Authors:  S Alonso; A Castro; I Fernandez; M Gómez de Cedrón; A Garcia-Orad; E Meyer; M Martínez de Pancorbo
Journal:  Int J Legal Med       Date:  1995       Impact factor: 2.686

3.  A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history.

Authors:  P A Underhill; L Jin; R Zemans; P J Oefner; L L Cavalli-Sforza
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

4.  Mutation rates from rare variants of proteins in Indian tribes.

Authors:  R Chakraborty; A K Roychoudhury
Journal:  Hum Genet       Date:  1978-08-31       Impact factor: 4.132

  4 in total

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