Literature DB >> 887936

Phase separation of a protein-water mixture in cold cataract in the young rat lens.

T Tanaka, C Ishimoto, L T Chylack.   

Abstract

A remarkable resemblance between the appearance of opacity in lysozyme--salt water mixtures and the development of opacity in cold cataract in the young rat lens is strong evidence that cold cataract is fundamentally a phase separation of the "protein-water binary mixture" in the lens.

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Year:  1977        PMID： 887936     DOI： 10.1126/science.887936

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

Review 1.  Protein interactions in the calf eye lens: interactions between beta-crystallins are repulsive whereas in gamma-crystallins they are attractive.

Authors:  A Tardieu; F Vérétout; B Krop; C Slingsby
Journal:  Eur Biophys J       Date:  1992       Impact factor: 1.733

2.  Phase separation of an IgG1 antibody solution under a low ionic strength condition.

Authors:  Hirotaka Nishi; Makoto Miyajima; Hiroaki Nakagami; Masanori Noda; Susumu Uchiyama; Kiichi Fukui
Journal:  Pharm Res       Date:  2010-04-17       Impact factor: 4.200

3.  Protein phase behavior in aqueous solutions: crystallization, liquid-liquid phase separation, gels, and aggregates.

Authors:  André C Dumetz; Aaron M Chockla; Eric W Kaler; Abraham M Lenhoff
Journal:  Biophys J       Date:  2008-01-15       Impact factor: 4.033

4.  Molecular basis of a progressive juvenile-onset hereditary cataract.

Authors:  A Pande; J Pande; N Asherie; A Lomakin; O Ogun; J A King; N H Lubsen; D Walton; G B Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

5.  Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.

Authors:  J Pande; C Berland; M Broide; O Ogun; J Melhuish; G Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

Review 6.  Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.

Authors:  Huan-Xiang Zhou; Xiaodong Pang
Journal:  Chem Rev       Date:  2018-01-10       Impact factor: 60.622

Review 7.  Self-organization across scales: from molecules to organisms.

Authors:  Tanumoy Saha; Milos Galic
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-05-26       Impact factor: 6.237

8.  Photon and fluorescence correlation spectroscopy and light scattering of eye-lens proteins at moderate concentrations.

Authors:  C Andries; W Guedens; J Clauwaert; H Geerts
Journal:  Biophys J       Date:  1983-09       Impact factor: 4.033

9.  Direct observation of delta-crystallin accumulation by laser light-scattering spectroscopy in the chicken embryo lens.

Authors:  S T Sun; T Tanaka; I Nishio; J Peetermans; J V Maizel; J Piatigorsky
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

10.  The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts.

Authors:  Claudia M Garcia; Ying-Bo Shui; Meera Kamath; Justin DeVillar; Randall S Johnson; Hans-Peter Gerber; Napoleone Ferrara; Michael L Robinson; David C Beebe
Journal:  Exp Eye Res       Date:  2008-08-20       Impact factor: 3.467
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