Literature DB >> 879760

Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate.

B Eriksson, E Helgstrand, N G Johansson, A Larsson, A Misiorny, J O Norén, L Philipson, K Stenberg, G Stening, S Stridh, B Oberg.   

Abstract

Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosine 5'-triphosphate and guanosine 5'-triphosphate. RTP also inhibits ApG- and GpC-stimulated influenza virus ribonucleic acid polymerase. Since ribavirin is phosphorylated in the cell, the inhibition of influenza multiplication in the cell may also be caused by RTP.

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Year:  1977        PMID： 879760      PMCID： PMC352108          DOI： 10.1128/AAC.11.6.946

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.

Authors:  J T Witkowski; R K Robins; R W Sidwell; L N Simon
Journal:  J Med Chem       Date:  1972-11       Impact factor: 7.446

2.  Genome homology of vesicular stomatitis virus and defective T particles and evidence for the sequential transcription of the virion ribonucleic acid.

Authors:  P Roy; D H Bishop
Journal:  J Virol       Date:  1972-06       Impact factor: 5.103

3.  Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion.

Authors:  D Baltimore; A S Huang; M Stampfer
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205

4.  A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase.

Authors:  R R Burgess
Journal:  J Biol Chem       Date:  1969-11-25       Impact factor: 5.157

5.  Animal DNA-dependent RNA polymerases. 1. Large-scale solubilization and separation of A and B calf-thymus RNA-polymerase activities.

Authors:  C Kedinger; F Gissinger; M Gniazdowski; J L Mandel; P Chambon
Journal:  Eur J Biochem       Date:  1972-07-13

6.  Polyacrylamide gel electrophoresis of influenza virus RNA.

Authors:  M W Pons; G K Hirst
Journal:  Virology       Date:  1968-02       Impact factor: 3.616

7.  Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

Authors:  R W Sidwell; J H Huffman; G P Khare; L B Allen; J T Witkowski; R K Robins
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

8.  Influenza virion transcriptase: synthesis in vitro of large, polyadenylic acid-containing complementary RNA.

Authors:  S J Plotch; R M Krug
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

9.  Inhibition of influenza RNA synthesis by virazole (ribavirin).

Authors:  C Scholtissek
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

10.  Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase.

Authors:  D H Bishop; J F Obijeski; R W Simpson
Journal:  J Virol       Date:  1971-07       Impact factor: 5.103
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  87 in total

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Authors:  J Rhodes
Journal:  Clin Exp Immunol       Date:  2002-12       Impact factor: 4.330

2.  Mechanism of action of ribavirin in the treatment of chronic hepatitis C.

Authors:  Helen S Te; Glenn Randall; Donald M Jensen
Journal:  Gastroenterol Hepatol (N Y)       Date:  2007-03

Review 3.  Microbe hunting.

Authors:  W Ian Lipkin
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

Review 4.  IMP dehydrogenase: structure, mechanism, and inhibition.

Authors:  Lizbeth Hedstrom
Journal:  Chem Rev       Date:  2009-07       Impact factor: 60.622

5.  Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.

Authors:  Evelien Vanderlinden; Bram Vrancken; Jeroen Van Houdt; Vivek K Rajwanshi; Sarah Gillemot; Graciela Andrei; Philippe Lemey; Lieve Naesens
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

6.  Molecular analysis of the inhibitory effect of phosphorylated ribavirin on the vesicular stomatitis virus in vitro polymerase reaction.

Authors:  R Fernandez-Larsson; K O'Connell; E Koumans; J L Patterson
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

7.  T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro.

Authors:  Tatiana Baranovich; Sook-San Wong; Jianling Armstrong; Henju Marjuki; Richard J Webby; Robert G Webster; Elena A Govorkova
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

8.  High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).

Authors:  William E Severson; Michael McDowell; Subramaniam Ananthan; Dong-Hoon Chung; Lynn Rasmussen; Melinda I Sosa; E Lucile White; James Noah; Colleen B Jonsson
Journal:  J Biomol Screen       Date:  2008-09-23

9.  Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice.

Authors:  Donald F Smee; Brett L Hurst; Min-Hui Wong; Kevin W Bailey; E Bart Tarbet; John D Morrey; Yousuke Furuta
Journal:  Antimicrob Agents Chemother       Date:  2009-11-09       Impact factor: 5.191

10.  Impact of alpha interferon and ribavirin on the function of maturing dendritic cells.

Authors:  Eleanor Barnes; Mariolina Salio; Vincenzo Cerundolo; Joanne Medlin; Shona Murphy; Geoffrey Dusheiko; Paul Klenerman
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191
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