Literature DB >> 19480389

IMP dehydrogenase: structure, mechanism, and inhibition.

Lizbeth Hedstrom1.   

Abstract

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Year:  2009        PMID： 19480389      PMCID： PMC2737513          DOI： 10.1021/cr900021w

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  257 in total

1.  Implications of selective type II IMP dehydrogenase (IMPDH) inhibition by the 6-ethoxycarbonyl-3,3-disubstituted-1,5-diazabicyclo[3.1.0]hexane-2,4-diones on tumor cell death.

Authors:  B J Barnes; A E Eakin; R A Izydore; I H Hall
Journal:  Biochem Pharmacol       Date:  2001-07-01       Impact factor: 5.858

2.  Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.

Authors:  N Minakawa; A Matsuda
Journal:  Curr Med Chem       Date:  1999-07       Impact factor: 4.530

3.  Inactivation of guanosine 5'-phosphate reductase by 6-chloro-, 6-mercapto-, and 2-amino-6-mercapto-9-beta-D-ribofuranosylpurine 5'-phosphates.

Authors:  L W Brox; A Hampton
Journal:  Biochemistry       Date:  1968-01       Impact factor: 3.162

4.  The growth of purine mutants of Bacillus anthracis in the body of the mouse.

Authors:  G Ivánovics; E Marjai; A Dobozy
Journal:  J Gen Microbiol       Date:  1968-09

5.  Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation.

Authors:  Y Liu; S A Bohn; J L Sherley
Journal:  Mol Biol Cell       Date:  1998-01       Impact factor: 4.138

6.  Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.

Authors:  F M McMillan; M Cahoon; A White; L Hedstrom; G A Petsko; D Ringe
Journal:  Biochemistry       Date:  2000-04-18       Impact factor: 3.162

7.  Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.

Authors:  Young Ok You; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2007-04-25       Impact factor: 3.162

8.  Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design.

Authors:  Nwakaso N Umejiego; Catherine Li; Thomas Riera; Lizbeth Hedstrom; Boris Striepen
Journal:  J Biol Chem       Date:  2004-07-21       Impact factor: 5.157

9.  Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate.

Authors:  W Wang; V V Papov; N Minakawa; A Matsuda; K Biemann; L Hedstrom
Journal:  Biochemistry       Date:  1996-01-09       Impact factor: 3.162

Review 10.  Mechanisms of action of ribavirin against distinct viruses.

Authors:  Jason D Graci; Craig E Cameron
Journal:  Rev Med Virol       Date:  2006 Jan-Feb       Impact factor: 6.989
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  135 in total

Review 1.  The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.

Authors:  L Hedstrom; G Liechti; J B Goldberg; D R Gollapalli
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

2.  Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.

Authors:  Meritxell Rovira; Wei Huang; Shamila Yusuff; Joong Sup Shim; Anthony A Ferrante; Jun O Liu; Michael J Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-14       Impact factor: 11.205

3.  Inter-ethnic variability of three functional polymorphisms affecting the IMPDH2 gene.

Authors:  Anne Garat; Christian Lacks Lino Cardenas; Arnaud Lionet; Aurore Devos; François Glowacki; Abderraouf Kenani; Florence Migot-Nabias; Delphine Allorge; Jean-Marc Lo-Guidice; Franck Broly; Christelle Cauffiez
Journal:  Mol Biol Rep       Date:  2010-12-23       Impact factor: 2.316

4.  The Bare Essentials of Antibiotic Target Validation.

Authors:  Lizbeth Hedstrom
Journal:  ACS Infect Dis       Date:  2016-11-09       Impact factor: 5.084

5.  Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

Authors:  Deviprasad R Gollapalli; Iain S Macpherson; George Liechti; Suresh Kumar Gorla; Joanna B Goldberg; Lizbeth Hedstrom
Journal:  Chem Biol       Date:  2010-10-29

6.  Adaptive evolution of drug targets in producer and non-producer organisms.

Authors:  Bjarne G Hansen; Xin E Sun; Hans J Genee; Christian S Kaas; Jakob B Nielsen; Uffe H Mortensen; Jens C Frisvad; Lizbeth Hedstrom
Journal:  Biochem J       Date:  2012-01-01       Impact factor: 3.857

7.  Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.

Authors:  Suresh Kumar Gorla; Yan Zhang; Meaghan M Rabideau; Aiping Qin; Shibin Chacko; Amanda L House; Corey R Johnson; Kavitha Mandapati; Hannah M Bernstein; Elizabeth S McKenney; Helena Boshoff; Minjia Zhang; Ian J Glomski; Joanna B Goldberg; Gregory D Cuny; Barbara J Mann; Lizbeth Hedstrom
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

8.  Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.

Authors:  Runhan Yu; Youngchang Kim; Natalia Maltseva; Philip Braunstein; Andrzej Joachimiak; Lizbeth Hedstrom
Journal:  Chem Res Toxicol       Date:  2019-02-25       Impact factor: 3.739

9.  Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

Authors:  Corey R Johnson; Suresh Kumar Gorla; Mandapati Kavitha; Minjia Zhang; Xiaoping Liu; Boris Striepen; Jan R Mead; Gregory D Cuny; Lizbeth Hedstrom
Journal:  Bioorg Med Chem Lett       Date:  2012-12-27       Impact factor: 2.823

10.  The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity.

Authors:  Iain S Macpherson; Sivapriya Kirubakaran; Suresh Kumar Gorla; Thomas V Riera; J Alejandro D'Aquino; Minjia Zhang; Gregory D Cuny; Lizbeth Hedstrom
Journal:  J Am Chem Soc       Date:  2010-02-03       Impact factor: 15.419
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