Literature DB >> 4340949

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.

R W Sidwell, J H Huffman, G P Khare, L B Allen, J T Witkowski, R K Robins.   

Abstract

Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A(O), A(2), and B viruses and parainfluenza 1 virus. infections is also effective.

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Year:  1972        PMID： 4340949     DOI： 10.1126/science.177.4050.705

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  238 in total

1.  Pharmacokinetics and metabolism of [(14)C]ribavirin in rats and cynomolgus monkeys.

Authors:  Chin-Chung Lin; Li-Tain Yeh; Trong Luu; David Lourenco; Johnson Y N Lau
Journal:  Antimicrob Agents Chemother       Date:  2003-04       Impact factor: 5.191

2.  Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Authors:  Lieven J Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung K Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

3.  Mechanism of action of ribavirin in the treatment of chronic hepatitis C.

Authors:  Helen S Te; Glenn Randall; Donald M Jensen
Journal:  Gastroenterol Hepatol (N Y)       Date:  2007-03

4.  Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins.

Authors:  Toru Yamaguchi-Sasaki; Seiken Tokura; Yuya Ogata; Takanori Kawaguchi; Yutaka Sugaya; Ryo Takahashi; Kanako Iwakiri; Tomoko Abe-Kumasaka; Ippei Yoshida; Kaho Arikawa; Hiroyuki Sugiyama; Kosuke Kanuma
Journal:  ACS Med Chem Lett       Date:  2020-04-10       Impact factor: 4.345

5.  Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice.

Authors:  Brett L Hurst; W Joseph Evans; Donald F Smee; Arnaud J Van Wettere; E Bart Tarbet
Journal:  Virology       Date:  2018-10-31       Impact factor: 3.616

Review 6.  The application and mechanism of action of ribavirin in therapy of hepatitis C.

Authors:  Emmanuel Thomas; Marc G Ghany; T Jake Liang
Journal:  Antivir Chem Chemother       Date:  2012-09-25

7.  Molecular analysis of the inhibitory effect of phosphorylated ribavirin on the vesicular stomatitis virus in vitro polymerase reaction.

Authors:  R Fernandez-Larsson; K O'Connell; E Koumans; J L Patterson
Journal:  Antimicrob Agents Chemother       Date:  1989-10       Impact factor: 5.191

8.  In vivo inhibition of respiratory syncytial virus by ribavirin.

Authors:  J F Hruska; P E Morrow; S C Suffin; R G Douglas
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

9.  T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro.

Authors:  Tatiana Baranovich; Sook-San Wong; Jianling Armstrong; Henju Marjuki; Richard J Webby; Robert G Webster; Elena A Govorkova
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

10.  Effect of ribavirin on subacute sclerosing panencephalitis virus infections in hamsters.

Authors:  Y Honda; M Hosoya; T Ishii; S Shigeta; H Suzuki
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191
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