| Literature DB >> 8696968 |
S W Englander1, T R Sosnick, J J Englander, L Mayne.
Abstract
Recent work has largely completed our understanding of the hydrogen-exchange chemistry of unstructured proteins and nucleic acids. Some of the high-energy structural fluctuations that determine the hydrogen-exchange behavior of native macromolecules have been explained; others remain elusive. A growing number of applications are exploiting hydrogen-exchange behavior to study difficult molecular systems and elicit otherwise inaccessible information on protein structure, dynamics and energetics.Entities:
Mesh:
Substances:
Year: 1996 PMID: 8696968 PMCID: PMC3412065 DOI: 10.1016/s0959-440x(96)80090-x
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN: 0959-440X Impact factor: 6.809