Literature DB >> 1384698

Effect of antibody binding on protein motions studied by hydrogen-exchange labeling and two-dimensional NMR.

L Mayne1, Y Paterson, D Cerasoli, S W Englander.   

Abstract

We have used hydrogen-exchange labeling detected by 2D NMR to study antibody-protein interactions for two monoclonal antibodies raised against horse cytochrome c. The data show that these antibodies bind mainly to the large 37-59 omega-loop of the cytochrome c molecule. In addition, the results provide some suggestive evidence concerning units of local structural flexibility in cytochrome c.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1384698     DOI： 10.1021/bi00159a006

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  19 in total

1.  Ligand binding to a high-energy partially unfolded protein.

Authors:  Joseph R Kasper; Chiwook Park
Journal:  Protein Sci       Date:  2014-12-05       Impact factor: 6.725

2.  Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.

Authors:  Sean R Marcsisin; John R Engen
Journal:  J Mol Biol       Date:  2010-08-20       Impact factor: 5.469

3.  Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.

Authors:  Jing Li; Hui Wei; Stanley R Krystek; Derek Bond; Ty M Brender; Daniel Cohen; Jena Feiner; Nels Hamacher; Johanna Harshman; Richard Y-C Huang; Susan H Julien; Zheng Lin; Kristina Moore; Luciano Mueller; Claire Noriega; Preeti Sejwal; Paul Sheppard; Brenda Stevens; Guodong Chen; Adrienne A Tymiak; Michael L Gross; Lumelle A Schneeweis
Journal:  Anal Chem       Date:  2017-02-09       Impact factor: 6.986

Review 4.  Protein complexes studied by NMR spectroscopy.

Authors:  A J Wand; S W Englander
Journal:  Curr Opin Biotechnol       Date:  1996-08       Impact factor: 9.740

Review 5.  Mechanisms and uses of hydrogen exchange.

Authors:  S W Englander; T R Sosnick; J J Englander; L Mayne
Journal:  Curr Opin Struct Biol       Date:  1996-02       Impact factor: 6.809

Review 6.  Hydrogen exchange mass spectrometry: are we out of the quicksand?

Authors:  Roxana E Iacob; John R Engen
Journal:  J Am Soc Mass Spectrom       Date:  2012-04-03       Impact factor: 3.109

7.  Identification of the epitopes of calcitonin gene-related peptide (CGRP) for two anti-CGRP monoclonal antibodies by 2D NMR.

Authors:  J A Hubbard; D P Raleigh; J R Bonnerjea; C M Dobson
Journal:  Protein Sci       Date:  1997-09       Impact factor: 6.725

8.  Hydrogen exchange and ligand binding: ligand-dependent and ligand-independent protection in the Src SH3 domain.

Authors:  David Wildes; Susan Marqusee
Journal:  Protein Sci       Date:  2004-12-02       Impact factor: 6.725

Review 9.  Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies.

Authors:  Hao Zhang; Weidong Cui; Michael L Gross
Journal:  FEBS Lett       Date:  2013-11-26       Impact factor: 4.124

10.  Architecture of a dsDNA viral capsid in complex with its maturation protease.

Authors:  David Veesler; Reza Khayat; Srinath Krishnamurthy; Joost Snijder; Rick K Huang; Albert J R Heck; Ganesh S Anand; John E Johnson
Journal:  Structure       Date:  2013-12-19       Impact factor: 5.006
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.