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Literature DB >> 8622960

Logarithm of odds (lods) for linkage in complex inheritance.

Abstract

Lod scores provide a method to unify linkage tests based on identity by descent and identity in marker state while permitting selection of the most informative individuals through their disease-related phenotypes and markers in relatives. After parametric lods are reviewed, a nonparametric approach that depends on a single logistic parameter beta is introduced. Lods for parents tested or unknown are derived, multiple pairwise mapping is presented, and power is shown to be good even for moderately small values of beta. Comparison of parametric and nonparametric approaches (yet to be made) will provide for polygenes the efficiency and reliability that lod scores gave to mapping of major loci 40 years ago.

Mesh：

Substances：
Genetic Markers

Year: 1996 PMID： 8622960 PMCID： PMC39633 DOI： 10.1073/pnas.93.8.3471

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

1. TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS.

Authors: C A SMITH
Journal: Ann Hum Genet Date: 1963-11 Impact factor: 1.670

2. Sequential tests for the detection of linkage.

Authors: N E MORTON
Journal: Am J Hum Genet Date: 1955-09 Impact factor: 11.025

3. LODs past and present.

Authors: N E Morton
Journal: Genetics Date: 1995-05 Impact factor: 4.562

4. Extreme discordant sib pairs for mapping quantitative trait loci in humans.

Authors: N Risch; H Zhang
Journal: Science Date: 1995-06-16 Impact factor: 47.728

5. Nonparametric tests for linkage with dependent sib pairs.

Authors: A Collins; N E Morton
Journal: Hum Hered Date: 1995 Nov-Dec Impact factor: 0.444

6. Linkage detection by the Affected-Pedigree-Member method: what is really tested?

Authors: M C Babron; M Martinez; C Bonaïti-Pellié; F Clerget-Darpoux
Journal: Genet Epidemiol Date: 1993 Impact factor: 2.135

7. Complete multipoint sib-pair analysis of qualitative and quantitative traits.

Authors: L Kruglyak; E S Lander
Journal: Am J Hum Genet Date: 1995-08 Impact factor: 11.025

8. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis.

Authors: D L Brown; M B Gorin; D E Weeks
Journal: Am J Hum Genet Date: 1994-03 Impact factor: 11.025

9. The investigation of linkage between a quantitative trait and a marker locus.

Authors: J K Haseman; R C Elston
Journal: Behav Genet Date: 1972-03 Impact factor: 2.805

10. The detection of major genes under additive continuous variation.

Authors: N E Morton
Journal: Am J Hum Genet Date: 1967-01 Impact factor: 11.025

14 in total

1. Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs.

Authors: J Dupuis; P Van Eerdewegh
Journal: Am J Hum Genet Date: 2000-06-26 Impact factor: 11.025

2. Pseudoautosomal linkage of Hodgkin disease.

Authors: A S Whittemore; M C Shih
Journal: Am J Hum Genet Date: 2000-08 Impact factor: 11.025

3. A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).

Authors: C Lonjou; K Barnes; H Chen; W O Cookson; K A Deichmann; I P Hall; J W Holloway; T Laitinen; L J Palmer; M Wjst; N E Morton
Journal: Proc Natl Acad Sci U S A Date: 2000-09-26 Impact factor: 11.205

Logarithm of odds (lods) for linkage in complex inheritance.

1. TESTING FOR HETEROGENEITY OF RECOMBINATION FRACTION VALUES IN HUMAN GENETICS.

2. Sequential tests for the detection of linkage.

3. LODs past and present.

4. Extreme discordant sib pairs for mapping quantitative trait loci in humans.

5. Nonparametric tests for linkage with dependent sib pairs.

6. Linkage detection by the Affected-Pedigree-Member method: what is really tested?

7. Complete multipoint sib-pair analysis of qualitative and quantitative traits.

8. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis.

9. The investigation of linkage between a quantitative trait and a marker locus.

10. The detection of major genes under additive continuous variation.

1. Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs.

2. Pseudoautosomal linkage of Hodgkin disease.

3. A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).

4. Testing genetic linkage with relative pairs and covariates by quasi-likelihood score statistics.

5. Individual disease risk and multimetric analysis of Crohn disease.

6. Tests and estimates of allelic association in complex inheritance.

7. Trials of the beta model for complex inheritance.

8. A metric map of humans: 23,500 loci in 850 bands.

9. Comparison of parametric and nonparametric methods to map oligogenes by linkage.

Review 10. Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study.