Literature DB >> 8314032

Linkage detection by the Affected-Pedigree-Member method: what is really tested?

M C Babron1, M Martinez, C Bonaïti-Pellié, F Clerget-Darpoux.   

Abstract

We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.

Mesh：

Substances：

Year:  1993        PMID： 8314032     DOI： 10.1002/gepi.1370100610

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  11 in total

Review 1.  Prospects for admixture mapping of complex traits.

Authors:  Paul M McKeigue
Journal:  Am J Hum Genet       Date:  2004-11-11       Impact factor: 11.025

2.  Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.

Authors:  L L Field; B J Kaplan
Journal:  Am J Hum Genet       Date:  1998-11       Impact factor: 11.025

3.  A general statistical model for detecting complex-trait loci by using affected relative pairs in a genome search.

Authors:  S L Smalley; J A Woodward; C G Palmer
Journal:  Am J Hum Genet       Date:  1996-04       Impact factor: 11.025

4.  Nonparametric simulation-based statistics for detecting linkage in general pedigrees.

Authors:  S Davis; M Schroeder; L R Goldin; D E Weeks
Journal:  Am J Hum Genet       Date:  1996-04       Impact factor: 11.025

5.  Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

Authors:  S D Detera-Wadleigh; J A Badner; L R Goldin; W H Berrettini; A R Sanders; D Y Rollins; G Turner; T Moses; H Haerian; D Muniec; J I Nurnberger; E S Gershon
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

6.  Parametric and nonparametric linkage analysis: a unified multipoint approach.

Authors:  L Kruglyak; M J Daly; M P Reeve-Daly; E S Lander
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

7.  Logarithm of odds (lods) for linkage in complex inheritance.

Authors:  N E Morton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

8.  Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15.

Authors:  E L Grigorenko; F B Wood; M S Meyer; L A Hart; W C Speed; A Shuster; D L Pauls
Journal:  Am J Hum Genet       Date:  1997-01       Impact factor: 11.025

9.  Model-free linkage analysis using likelihoods.

Authors:  D Curtis; P C Sham
Journal:  Am J Hum Genet       Date:  1995-09       Impact factor: 11.025

10.  Two-locus disease models with two marker loci: the power of affected-sib-pair tests.

Authors:  M Knapp; S A Seuchter; M P Baur
Journal:  Am J Hum Genet       Date:  1994-11       Impact factor: 11.025
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.