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Literature DB >> 8618933

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

A Migliazza¹, S Martinotti, W Chen, C Fusco, B H Ye, D M Knowles, K Offit, R S Chaganti, R Dalla-Favera.

Abstract

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 x 10(-3) -1.6 x 10(-2) per bp), often biallelic, mutations clustering in its 5' noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BLC6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.

Entities: Disease Gene

Mesh：

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Year: 1995 PMID： 8618933 PMCID： PMC40389 DOI： 10.1073/pnas.92.26.12520

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.

Authors: G Gaidano; R S Hauptschein; N Z Parsa; K Offit; P H Rao; G Lenoir; D M Knowles; R S Chaganti; R Dalla-Favera
Journal: Blood Date: 1992-10-01 Impact factor: 22.113

Review 2. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways.

Authors: C Kocks; K Rajewsky
Journal: Annu Rev Immunol Date: 1989 Impact factor: 28.527

3. Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.

Authors: J Menezes; W Leibold; G Klein; G Clements
Journal: Biomedicine Date: 1975-07

4. Antibody diversity: somatic hypermutation of rearranged VH genes.

Authors: S Kim; M Davis; E Sinn; P Patten; L Hood
Journal: Cell Date: 1981-12 Impact factor: 41.582

5. Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation.

Authors: H Ikematsu; N Harindranath; Y Ueki; A L Notkins; P Casali
Journal: J Immunol Date: 1993-02-15 Impact factor: 5.422

9. Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma.

Authors: Z Szereday; B Csernus; M Nagy; T László; R A Warnke; A Matolcsy
Journal: Am J Pathol Date: 2000-03 Impact factor: 4.307

Review 10. Molecular pathology of lymphoma.

Authors: S E Coupland
Journal: Eye (Lond) Date: 2012-12-07 Impact factor: 3.775

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

1. Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.

Review 2. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways.

3. Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.

4. Antibody diversity: somatic hypermutation of rearranged VH genes.

5. Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation.

6. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma.

7. The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

8. Analysis of RAS oncogene mutations in human lymphoid malignancies.

9. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas.

10. The presence of clonogenic cells in high-grade malignant lymphoma: a prognostic factor.

Review 1. Gene expression profiling of lymphomas.

Review 2. A new class of errant DNA polymerases provides candidates for somatic hypermutation.

Review 3. The reverse transcriptase model of somatic hypermutation.

Review 4. Molecular regulation of cytokine gene expression during the immune response.

Review 5. Somatic immunoglobulin hypermutation.

6. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas.

7. Peripheral T-cell lymphoma with involvement of the expanded mantle zone.

8. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

9. Somatic mutation of the 5' noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma.

Review 10. Molecular pathology of lymphoma.