Literature DB >> 11205332

The reverse transcriptase model of somatic hypermutation.

E J Steele1, R V Blanden.   

Abstract

The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.

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Year:  2001        PMID： 11205332      PMCID： PMC1087692          DOI： 10.1098/rstb.2000.0749

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  44 in total

Review 1.  Defining the nucleic acid substrate for somatic hypermutation.

Authors:  E J Steele; H S Rothenfluh; G W Both
Journal:  Immunol Cell Biol       Date:  1992-04       Impact factor: 5.126

2.  Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

Authors:  G W Both; L Taylor; J W Pollard; E J Steele
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

3.  Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.

Authors:  J S Weber; J Berry; T Manser; J L Claflin
Journal:  J Immunol       Date:  1991-05-15       Impact factor: 5.422

4.  Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region.

Authors:  A G Betz; C Milstein; A González-Fernández; R Pannell; T Larson; M S Neuberger
Journal:  Cell       Date:  1994-04-22       Impact factor: 41.582

5.  Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

Authors:  H S Rothenfluh; L Taylor; A L Bothwell; G W Both; E J Steele
Journal:  Eur J Immunol       Date:  1993-09       Impact factor: 5.532

6.  Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes.

Authors:  R M Gerstein; W N Frankel; C L Hsieh; J M Durdik; S Rath; J M Coffin; A Nisonoff; E Selsing
Journal:  Cell       Date:  1990-11-02       Impact factor: 41.582

7.  Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.

Authors:  A Umar; P A Schweitzer; N S Levy; J D Gearhart; P J Gearhart
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

8.  A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation.

Authors:  M Hengstschläger; M Williams; N Maizels
Journal:  Eur J Immunol       Date:  1994-07       Impact factor: 5.532

9.  Somatic mutation in constant regions of mouse lambda 1 light chains.

Authors:  N Motoyama; H Okada; T Azuma
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

10.  Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation.

Authors:  A M Giusti; T Manser
Journal:  J Exp Med       Date:  1993-03-01       Impact factor: 14.307
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  1 in total

Review 1.  Mutating for Good: DNA Damage Responses During Somatic Hypermutation.

Authors:  Bas Pilzecker; Heinz Jacobs
Journal:  Front Immunol       Date:  2019-03-12       Impact factor: 7.561
  1 in total

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